Brucellosis is a worldwide zoonosis causing reproductive failures in livestock. It is shown that although the vaccine can prevent abortion, it does not provide complete protection against infection. So that vaccination of ewes with Rev.1 biotype can be a source of cattle and even human Brucellosis. The aim of this study was to evaluate possibility of Brucella cross-infection in cattle from Bruc...

Brucella species are important human and animal pathogens. Though, only little is known about mobile genetic elements of these highly pathogenic bacteria. To date, neither plasmids nor temperate phages have been described in brucellae. We analyzed genomic sequences of various reference and type strains and identified a number of putative prophages residing within the Brucella chromosomes. By in...

Rheumatic fever (RF) is a prevalent healthcare problem in the developing countries. Recurrence of this disorder is often observed in childhood and adolescence. RF can mimic the presentations of infective endocarditis, and clinicians are not really familiar with this issue. Herein, we present a case of recurrent acute rheumatic fever in a patient suspicious of acute bacterial endocarditis due to...

The American Heart Association (AHA) has provided new guidelines for infective endocarditis prophylaxis in dentistry. In this paper, written for dentists, major changes in the updated recommendations which dentists should be aware have been discussed. These recommendations address the impact of oral hygiene and type of dental procedures on high-risk patients, risk of adverse reactions of antibi...

Assessing Brucella ceti Infections in Oregon and Washington Dolphins that Stranded with Histopathological Lesions Resembling Neurobrucellosis, 2006-2014 Tabitha George This thesis documents the presence of Brucella ceti in the Pacific white-sided dolphin (Lagenorhynchus obliquidens), striped dolphins (Stenella coeruleoalba), and shortbeaked common dolphins (Delphinus delphis) that stranded with...

Previous findings indicate that Brucella antigens and those from nonpathogenic alphaproteobacteria (NPAP) are cross-recognized by the immune system. We hypothesized that immunization with NPAP would protect mice from Brucella infection. Mice were immunized subcutaneously with heat-killed Ochrobactrum anthropi, Sinorhizobium meliloti, Mesorhizobium loti, Agrobacterium tumefaciens, or Brucella me...

In this study, a localized surface plasmon resonance (LSPR) nanobiosensor was designed to quantify anti-Brucella antibodies in the human sera. Smooth Lipopolysaccharide (LPS) extracted from Brucella melitensis via modified hot phenol water method and fixed on of gold nanoparticles by covalent interactions with functionalized nanoparticles. To obtain best performance probe, ratio LPS nanoparticl...

Brucella spp. are facultative intracellular parasitic pathogens that can survive and multiply in professional and nonprofessional phagocytes. These pathogens are responsible for brucellosis, which can cause abortion in domestic animals and undulant fever in humans. Brucella spp. can survive in a variety of cells and their virulence and chronic infections are thought to be due to their ability t...

There are few studies about post-cardiac surgery fungal infections especially by Aspergillus fumigatus. In this paper we report a case of Aspergillus fumigatus endocarditis after tetralogy of Fallot total correction (TFTC), and permanent pacemaker (PPM) implantation. A five-year-old female patient with current history of total correction of tetralogy of fallot was admitted in Rajaie Ca...

Bacterial endocarditis is the infection of inner lining of heart and /or heart valves. This disease is usually related to the presence of some pathogenic bacteria in mouth, digestive system or urinary tract. Most of the times, this infection happens in people with heart problems like the presence of prosthetic valves, history of previous endocarditis, some congenital heart defects and heart tra...