Esophageal cancer represents the fourth most common gastrointestinal cancer and generally confers a poor prognosis. Prostaglandin-producing cyclo-oxygenase has been implicated in the pathogenesis of esophageal cancer growth. Here we report that prostaglandin dehydrogenase, the major enzyme responsible for prostaglandin degradation, is significantly reduced in expression in esophageal cancer in ...

background: irritable bowel syndrome (ibs) is one of the most prevalent gastrointestinal disorders, characterized by non-specific symptoms such as abdominal pain and altered bowel habit without any organic pathology. its prevalence varies in human communities. we performed this study to determine the prevalence of ibs in medical students of gilan university of medical sciences (gums). materials...

IMPORTANCE Burden of disease should inform research prioritization. OBJECTIVE To determine whether systematic reviews and protocols published in the Cochrane Database of Systematic Reviews (CDSR) appropriately reflect disease burden for otolaryngologic conditions as measured by the Global Burden of Disease (GBD) 2010 project. DESIGN Two investigators independently assessed 10 otolaryngologi...

Esophageal cancer, which consist of esophageal adenocarcinoma and esophageal squamous cell carcinoma, is one of the most common malignant tumors in the world, especially in the south of Iran and China. To find and investigate the biomarkers in the initiation, development and progression of esophageal cancer will help us predict the prognosis of esophageal cancer patients and improve the curativ...

Esophageal cancer is one of the most common malignant tumors of the digestive tract. The greatest obstacle to the curing of esophageal cancer is its propensity to spread and metastasize. Esophageal cancer stem cells are considered the source for recurrence and metastasis of the tumors. While clinical evidence suggested that continuous up-regulation of CXCL12/CXCR4 was significantly associated w...

background : esophageal cancer is a major clinical problem that has a generally poor prognosis. as a result, there has been interest in combining surgery with neoadjuvant chemotherapy in an attempt to improve clinical outcomes. evidence for clinical benefit from preoperative chemotherapy exists but it is not clear which patients (stage, tumor location, and histology) will benefit the most from ...

AIM To understand the molecular mechanism of esophageal cancer development and provide molecular markers for screening high-risk populations and early diagnosis. METHODS Two-dimensional electrophoresis combined with mass spectrometry were adopted to screen differentially expressed proteins in nine cases of fetal esophageal epithelium, eight cases of esophageal cancer, and eight cases of tumor...

OBJECTIVE To investigate the relationship between Tiam1 gene expression and the invasion and metastasis of esophageal cancer. METHODS By RT-PCR technique, Tiam1 mRNA expression levels in 49 cases of esophageal cancer tissues and normal esophageal tissues were detected. RESULTS Average Tiam1 mRNA expression level in 49 cases of esophageal cancer tissues (1.83 ± 0.73) was significantly higher...

Esophageal cancer, usually involve esophageal squamous cell carcinoma (SCC) and esophageal adenocarcinoma (AC), is one of the most common malignant tumors in the world [1]. Esophageal cancer is the sixth leading cause of cancer death in the world [2]. Esophageal squamous-cell carcinoma and esophageal adenocarcinoma represent the core histological subtypes of esophagus cancer [3]. Esophageal car...