A feeding trial was conducted for sixty continuous days to determine the effect of dietary Aloe vera and Echinacea  on immunological parameters of Shirbot (Barbus grypus) Four hundred and twenty fish weighing 50-60 g were randomly subjected to to seven different treatment, including one control  (Aloe vera and Echinacea free diet), A1 (0.1% of Aloe vera, A2 (0.2% of Aloe vera &nb...

Objective(s): Drug-induced atrial fibrillation (AF) is considered an adverse effect of chemotherapeutic drugs. AF is a crucial risk factor for stroke, heart failure, myocardial infarction, and mortality. Pulmonary veins (PVs) are considered triggers inducing AF, and the sinoatrial node (SAN) may modulate PV activity and participate in AF genesis. AF was associated with...

Purpose: Delirium is a fatal but potentially reversible disorder of Central Nervous System that adds a lot of costs on health systems. The aim of this study was to evaluate the effect of intermittent theta burst stimulation on severity and course of delirium. Methods: This was a double-blind, randomized, sham-controlled, pilot study. The participants were randomly allocated into two groups of ...

objective: the purpose of this study was to investigate the role of fast inactivating (ia) voltage dependent potassium channels in shaping the discharge activity of cerebellar purkinje cells (pcs) in ataxic rats. materials and methods: male sprauge-dawley rats (40-60 g) were used in this study. ataxia was induced via single i.p. injection of 3-acethylpyridine (65 mg/kg). four days following ind...

Complement plays an essential role in inflammation and tissue damage. However, it is largely unknown to what extent the system acts as a primary inducer of secondary mediator systems in the inflammatory network of human whole blood. Here we describe a novel in vitro model using the thrombin-specific hirudin analog lepirudin as anticoagulant, which, in contrast to heparin, did not interfere with...

BACKGROUND Advanced glycation end products (AGEs) enhance NADPH oxidase, and hence respiratory burst activity, of stimulated neutrophils. They are thus potentially vasculopathic, especially in diabetes, uremia, and aging, in which AGEs classically accumulate. We investigated the underlying mechanisms. METHODS AND RESULTS Neutrophils prelabeled with [3H]arachidonic acid display increased [3H]a...

Dietary long-chain n-3 PUFA (n-3 LCPUFA) are thought to have immune-modulating effects, but the specific effects and mechanisms are not fully elucidated. The aim of this study was to determine whether dietary n-3 LCPUFA could affect ex vivo oxidative burst in healthy young men. The study had a randomised 2 x 2-factorial design in which subjects were randomly assigned to 8-week supplementation w...

We investigate the effect of network architecture on burst and spike synchronization in a directed scale-free network (SFN) of bursting neurons, evolved via two independent α- and β-processes. The α-process corresponds to a directed version of the Barabási-Albert SFN model with growth and preferential attachment, while for the β-process only preferential attachments between pre-existing nodes a...

Neutrophils are important effector cells in innate and acquired immunity, but the magnitude and character of their phagocytic and bactericidal responses depend on cues derived from mediators in the local microenvironment. This study investigated the effect of bovine interleukin-8 (IL-8) and granulocyte colony-stimulating factor (G-CSF) on priming and activation of bovine neutrophils in vitro an...

All gamma-ray bursts are observed to have approximately the same characteristic gamma-ray energy. We show in this article that for bursts in the BATSE data set, this property as measured by the E-peak value is not an instrumental effect, but a physical property of gamma-ray bursts. 1. The Characteristic Photon Energy of Bursts The prompt emission of gamma-ray bursts is observed predominately at...