A new polyether antibiotic, lonomycin, was isolated from the culture of Streptomyces ribosidifcus strain TM-481. The antibiotic obtained as a sodium salt is a colorless prism having a molecular formula of C44H75O14Na(M.W. 850), m.p. 188 approximately 189 degrees C, and has no absorption maxima in the ultraviolet region. The infrared and NMR spectra of the antibiotic suggest the presence of a ca...

A new antibiotic, setomimycin, was isolated from the culture broth of strain AM-2947, which was identified as Streptomyces pseudovenezuelae. The compound is a weakly acidic substance, and has UV-absorption at 228, 268 and 422 nm and a molecular formula of C34H28O9 (MW 580). It is active against Gram-positive bacteria including Mycobacteria, and has antitumor activity against Sarcoma-180 solid t...

Antibiotic DE-3936 was isolated from the fermentation broth of a streptomycete No. 9735-1, which is identified as a strain of Streptomyces hygroscopicus. The antibiotic is a hydrophobic compound having the molecular formula of of C44H75O14Na and is active against Gram-positive bacteria, mycobacteria, mycoplasma and protozoa, especially coccidia. Its chemical and biological properties indicate ...

The dnaK operon from Bacillus subtilis and other Gram-positive bacteria with low G + C DNA content contains additional heat-shock genes, including hrcA. The hrcA gene encodes a transcription factor that negatively regulates heat-shock genes and is uniformly present in all Gram-positive bacteria studied to date. An hrcA homologue is also present in Synechocystis species, Leptospira interrogans, ...

INTRODUCTION Streptomyces, gram-positive and aerobic bacteria, are distinguished genus of Actinomycetes. This economically important genus is well studied owing to its capacity in producing more than 70% of antibiotics. In fact, need for novel, safe and more efficient antibiotics is a key challenge to the pharmaceutical industry today, moreover, increase in opportunistic infections in the immun...

Abstract An antimicrobial producing Gram-positive, aerobic, non-motile and filamentous actinobacterial strain SKN60T was isolated from soil The isolate exhibited 99.3 99.0% identity with Streptomyces laurentii ATCC 31255T S. roseicoloratus TRM 44457T, respectively, in 16S rRNA gene sequence analysis. However, the genome displayed maximum ANI (88.45%) AAI (85.61%) 44457T. Similarly, dDDH showed ...

Streptomyces is a genus of Gram-positive bacteria that grows in various environments, and its shape resembles filamentous fungi. The morphological differentiation of Streptomyces involves the formation of a layer of hyphae that can differentiate into a chain of spores. The most interesting property of Streptomyces is the ability to produce bioactive secondary metabolites, such as antifungals, a...

Tetronasin (formerly ICI139603) [l] is a polyether polyketide antibiotic produced during the aerobic growth of the Gram-positive soil organism Streptomyces longisporofluvus. It has been used c o m i a l l y as a cattle food additive where it has been found to improve food utilisation [2] and to combat the onset of acid lactosis [3]. It may well also prove to be commercially viable as an anticwi...

The Gram-positive bacterium B. cereus produces both -lactamase I, a class A serine enzyme, and -lactamase II, a zinc dependent enzyme of class B. Crystallographic studies of these two enzymes have shown that -lactamase I is homologous with the penicillin-sensitive D-alaD-ala carboxypeptidase-transpeptidase of Streptomyces R61 while -lactamase II has a hitherto unknown structure. New methods of ...