Cancer is a disease that still difficult to identify up today. One of the causes cancer genetic modification because mutations in p53 gene. Healthy cells have wild type protein (normal) able manage DNA separation. If mutates, it will be detect composition has changed. Bioinformatics combination biology and information engineering (TI) utilized data. applications data mining bioinformatics devel...

The paper treats the application of the micromagnetic method to the determination of hardness of C45 hardened-and-tempered steel on the basis of a voltage signal of the magnetic Barkhausen noise, The specimens were hardened and tempered at different temperatures so that small differences in hardness of individual specimens and, consequently, small differences in captured voltage signals were ob...

The electron transfer molecules plastoquinone and ubiquinone are formed by the condensation of aromatic head groups with long-chain prenyl diphosphates. In the present paper we report the cloning and characterization of two genes from tomato (Solanum lycopersicum) responsible for the production of solanesyl and decaprenyl diphosphates. SlSPS (S. lycopersicum solanesyl diphosphate synthase) is t...

We study a model where agents, located in a social network, decide whether to exert e¤ort or not in experimenting with a new technology (or acquiring a new skill, innovating, etc.). We assume that agents have strong incentives to free ride on their neighbors’e¤ort decisions. In the static version of the model e¤orts are chosen simultaneously. In equilibrium, agents exerting e¤ort are never conn...

The ISO Reference Model of Open Distributed Processing (RM-ODP) consists of four parts an Overview of the reference model, the Descriptive Model, the Prescriptive Model, and the Architectural Semantics. The four parts provide the concepts and rules of distributed processing to ensure openness between interacting distributed application components. Openness is a combination of characteristics, i...

We estimated the past and future age-standardised incidence rates of mesothelioma by birth cohort and by period of diagnosis in South East England. We extracted data on patients diagnosed with mesothelioma (International Classification of Diseases-10 C45) between 1960 and 2009 from the Thames Cancer Registry. We calculated the age-standardised incidence rates using the European standard populat...

multiple traveling salesman problem (mtsp) is one of the most popular operation research problem and is known as combinatorial optimization problems. mtsp is an extension version of the famous and widely used problem named traveling salesman problem (tsp). because of its benefices in various domains, many researchers have tried to solve that, and many methods have proposed so far. mtsp is a np-...

Glycogen constitutes the major carbon storage source in cyanobacteria, as starch in algae and higher plants. Glycogen and starch synthesis is linked to active photosynthesis and both of them are degraded to glucose in the dark to maintain cell metabolism. Control of glycogen biosynthesis in cyanobacteria could be mediated by the regulation of the enzymes involved in this process, ADP-glucose py...

We examined the inhibitory effects of three flavonolignans and their dehydro- derivatives, taxifolin and quercetin on the activity of the Na(+)/K(+)-ATPase (NKA). The flavonolignans silychristin, dehydrosilychristin and dehydrosilydianin inhibited NKA with IC50 of 110 ± 40 μM, 38 ± 8 μM, and 36 ± 14 μM, respectively. Using the methods of molecular modeling, we identified several possible bindin...

Regulators require financial institutions to estimate counterparty default risks from liquid CDS quotes for the valuation and risk management of OTC derivatives. However, the vast majority of counterparties do not have liquid CDS quotes and need proxy CDS rates. Existing methods cannot account for counterparty-specific default risks; we propose to construct proxy CDS rates by associating to ill...