Postmenopausal women represent a vulnerable population towards endocrine disruptors due to hormonal deficit. We previously demonstrated that chronic exposure of ovariectomized C57Bl6/J mice fed high-fat, high-sucrose diet low-dose mixture chemicals with one dioxin, polychlorobiphenyl, phthalate, and bisphenol A triggered metabolic alterations in the liver but intestine was not explored. Yet, ga...

Melanocyte regeneration in epidermis (e.g., vitiligo) and matrix of hair follicle graying hair) is quite dependent on the migration melanocyte precursors located follicle. We have demonstrated that casein kinase (CK) 1 ablation keratinocytes increases eumelanin production epidermal numbers. Here we further evaluate effect CK1 inhibition first established Fusion Red-labelled-melanocyte reporter ...

It has been well established that physical activity (exercise) by way of running wheel or treadmill activity improves motor and cognitive performance in (sedentary) mice [1,2,3]. This type of exercise, however, cannot be performed well by aging mice or mice with motor deficiencies. Notably the amount of voluntary exercise of old mice in running wheels decreases largely (up to 90% as compared to...

Abstract Background Genomic instability is a hallmark of various cancers, and DNA repair an essential process for maintaining genomic integrity. Mammalian cells have developed mechanisms in response to damage. Compared the cellular damage, vivo damage (DDR) specific tissues has not been studied extensively. Objective In this study, mice were exposed whole-body gamma (γ)-irradiation evaluate DDR...