Single nucleotide polymorphisms (SNPs) are a hot item in current discussions about the practical applications of genomics and Human Genome Project research. SNPs are simply DNA point mutations—single base-pair changes or insertion/deletions—that are present at measurable frequencies in the population. SNPs are the most common variations in the human genome; the current estimate is that SNPs occ...

Single nucleotide polymorphisms (SNPs) are an abundant form of genome variation, distinguished from rare variations by a requirement for the least abundant allele to have a frequency of 1% or more. A wide range of genetics disciplines stand to benefit greatly from the study and use of SNPs. The recent surge of interest in SNPs stems from, and continues to depend upon, the merging and coincident...

Staphylococcus aureus stifles its host's immune response by producing an immunosuppressive molecule, report Thammavongsa and colleagues. The new study reveals that without the cell wall enzyme adenosine synthase A (AdsA), most staphylococci fail to thrive and cause severe disease in mice. The gene encoding AdsA contains a 5 Ј-nucleotidase domain, making it similar to a family of mammalian enzym...

Genome-scale networks can now be reconstructed based on high-throughput data sets. Mathematical analyses of these networks are used to compute their candidate functional or phenotypic states. Analysis of functional states of networks shows that the activity of biochemical reactions can be highly correlated in physiological states, forming so-called co-sets representing functional modules of the...

Copyright: © 2008 David Fay and Aaron Bender. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. To whom correspondence should be addressed. E-mail: [email protected] SNPs: Introduction and two-point mapping* Dav...

objective: basal cell carcinoma (bcc) is the most common human malignant neoplasm which is more frequent in white individuals. ptch and p53 are two major tumor suppressor genes which play important roles in pathogenesis of bcc. ptch is a twelve-pass transmembrane protein. it is an essential component of the sonic hedgehog signaling pathway that plays as a receiving receptor for members of the h...

Porcine Reproductive and Respiratory Syndrome (PRRS) is a viral disease that seriously affects the swine industry. The main method of control vaccination, which has shown variable effectiveness partly attributed to genetic variability in sows. objective was validate single-nucleotide polymorphisms (SNPs) associated with performance traits following PRRS vaccination replacement A population 100 ...