BACKGROUND Idiopathic pulmonary fibrosis (IPF) is a common, progressive and invariably lethal interstitial lung disease with no effective therapy. We hypothesised that K(Ca)3.1 K(+) channel-dependent cell processes contribute to IPF pathophysiology. METHODS K(Ca)3.1 expression in primary human lung myofibroblasts was examined using RT-PCR, western blot, immunofluorescence and patch-clamp elec...

The present study was designed to test the hypothesis that in cerebral arteries of the fetus, ATP-sensitive (K(ATP)) and Ca(2+)-activated K(+) channels (K(Ca)) play an important role in the regulation of intracellular Ca(2+) concentration ([Ca(2+)](i)) and that this differs significantly from that of the adult. In main branch middle cerebral arteries (MCA) from near-term fetal ( approximately 1...

STIM1 'senses' decreases in endoplasmic reticular (ER) luminal Ca(2+) and induces store-operated Ca(2+) (SOC) entry through plasma membrane Orai channels. The Ca(2+)/calmodulin-activated K(+) channel K(Ca)3.1 (previously known as SK4) has been implicated as an 'amplifier' of the Ca(2+)-release activated Ca(2+) (CRAC) current, especially in T lymphocytes. We have previously shown that human macr...

هدف: هدف از این مطالعه بررسی اثر سینامیک‌اسید (CA) بر برخی خصوصیات فیزیولوژیکی و میزان تحمل‌به‌شوری گیاه‌تنباکو (Nicotiana rustica L.) می‌باشد.مواد روش‌ها: در قطعات جداکشت گیاه تنباکو رشد‌یافته محیط MS به محیط‌های کشت حاوی (غلظت‌های 0، 5، 10 20 میلی‌گرم‌در‌لیتر) نمک NaCl 100 200 میلی‌مولار) منتقل‌گردید. پس چهار هفته فعالیت آنزیم فنیل‌آلانین‌آمونیالیاز (PAL) تیروزین‌آمونیالیاز (TAL) ، ترکیبات‌فن...