The effects of systemic administration of calcitonin gene-related peptide (CGRP) on survival and inflammation of experimental skin flaps subjected to prolonged arterial ischemia were studied. An island groin flap was elevated in the rat. The femoral artery was occluded for 8, 10, 12 or 14 h in four groups of 10 rats. In a group of 10 sham-operated control animals, the femoral artery was not occ...

Nonadrenergic noncholinergic nerve fibers supposedly modulate basal coronary flow by releasing capsaicin-sensitive neuropeptides, but the physiological effects of this intrinsic action have not been clarified. We investigated the intrinsic function of nonadrenergic noncholinergic innervation in modulating basal coronary flow in rats. We administered capsaicin to 44 rats to deplete neuropeptides...

The management of patients with migraine is often unsatisfactory because available acute and preventive therapies are either ineffective or poorly tolerated. The acute treatment of migraine attacks has been limited to the use of analgesics, combinations of analgesics with caffeine, ergotamines, and the triptans. Successful new approaches for the treatment of acute migraine target calcitonin gen...

Migraine is a common, chronic disorder of the brain causing much disability, as well as personal, familial and societal impact. Several oral preventive agents are available in different countries for the prevention of migraine, but none have performed better than 50% improvement in 50% of patients in a clinical trial. Additionally, each has various possible adverse events making their tolerabil...

This receptor family comprises a group of receptors for the calcitonin/CGRP peptides. The calcitonin (CT), amylin (AMY), gene-related peptide (CGRP) and adrenomedullin (AM) (nomenclature as agreed by NC-IUPHAR Subcommittee on CGRP, AM, AMY, CT [131, 74, 71]) are generated genes CALCR (which codes receptor, CTR) CALCRL receptor-like CLR, previously known CRLR). Their function pharmacology altere...

Calcitonin and ·-CGRP are products of the alternatively spliced gene CALCA. Calcitonin (CALC) mRNA is predominantly found in thyrodial C cells and mRNA encoding the neuropeptide calcitonin gene-related peptide (CGRP) in neural tissues (Amara et al., 1982, Rosenfeld et al., 1983). In vivo, calcitonin reduces serum calcium and acts as an antagonist to the parathyroid hormone. The human CALC-A/·-C...

Depuis 2018, trois antagonistes du calcitonin gene-related peptide sont commercialisés en Europe, l’érénumab, le frémanézumab et galcanézumab. Si cette nouvelle classe pharmacologique est perçue comme prometteuse par les neurologues pour la prévention des crises chez patients migraineux, elle pose d’importantes questions de sécurité sur plan cardio-vasculaire. Since three antagonists have been ...

Modelling class B G-protein-coupled receptors (GPCRs) using class A GPCR structural templates is difficult due to lack of homology. The plant GPCR, GCR1, has homology to both class A and class B GPCRs. We have used this to generate a class A-class B alignment, and by incorporating maximum lagged correlation of entropy and hydrophobicity into a consensus score, we have been able to align recepto...