Introduction: Although originally considered a white matter (WM) disease, it is now clear that focal cortical grey matter (GM) pathology is an important component of multiple sclerosis (MS). Presently available magnetic resonance imaging (MRI) techniques fail in detecting the actual amount of cortical lesions (CLs). The reason for such a failure is twofold: (i) the small size of CLs relative to...

The manipulation of nutrient-signaling pathways in yeast has uncovered the impact of environmental growth conditions in longevity. Studies using calorie restriction show that reducing glucose concentration of the culture media is sufficient to increase replicative and chronological lifespan (CLS). Other components of the culture media and factors such as the products of fermentation have also b...

Background: In vitro angiogenesis assays were first described in the early 1980s, when it was found that endothelial cells form capillary-like structures (CLS) on matrices of collagen, laminin or fibrin. These assays have been useful in unravelling some of the molecular steps involved in angiogenesis, as well as in screening potential angiogenesis inhibitors. Aim: The aim of our current study w...

We studied the role of peroxisomal catalase in chronological aging of the yeastHansenula polymorpha in relation to various growth substrates. Catalase-deficient (cat) cells showed a similar chronological life span (CLS) relative to the wild-type control upon growth on carbon and nitrogen sources that are not oxidized by peroxisomal enzymes. However, when media contained methylamine, which is ox...

In this paper, we consider the circular Cauchy distribution μx on the unit circle S with index 0 ≤ |x| < 1 and we study the spectral gap and the optimal logarithmic Sobolev constant for μx, denoted respectively by λ1(μx) and CLS(μx). We prove that 1 1+|x| ≤ λ1(μx) ≤ 1 while CLS(μx) behaves like log(1 + 1 1−|x| ) as |x| → 1.

In this article we present our work on the specification of a learning environment allowing a teacher to implement co-operative learning situations (CLS) based on the notion of situational problems. To this end, we approach the specifications of our environment based on a meta model that we define to support CLS.

Ultrafast two-dimensional infrared (2D-IR) vibrational echo spectroscopy can probe structural dynamics under thermal equilibrium conditions on time scales ranging from femtoseconds to approximately 100 ps and longer. One of the important uses of 2D-IR spectroscopy is to monitor the dynamical evolution of a molecular system by reporting the time dependent frequency fluctuations of an ensemble of...

This work presents a systematic study of cellulose (CLS) as a sacrificial biomass for photocatalytic H2 evolution from water. The idea is indeed to couple a largely available and not expensive biomass, and water, with a renewable energy like solar radiation. An aqueous CLS suspension irradiated either at 366 nm (UV-A) or under sunlight in the presence of Pt/TiO2 behaves as a H2 evolving system....

We investigated the global landscape of Ca2+ homeostasis in budding yeast based on high-dimensional chemical-genetic interaction profiles. The morphological responses of 62 Ca2+-sensitive (cls) mutants were quantitatively analyzed with the image processing program CalMorph after exposure to a high concentration of Ca2+ After a generalized linear model was applied, an analysis of covariance mode...