RENAL CALCIFICATION, INDUCED IN RATS BY AN INJECTION OF URANIUM, IS ACCOMPLISHED IN TWO STAGES: a primary accumulation of calcium in association with anions other than phosphate and a secondary conversion of this calcium complex into a precipitate of calcium phosphate. Except for the exclusion of chondroitin sulfate, the nature of the primary anions remains undefined. The accumulation of calciu...

Anion transporters NaS1 (SLC13A1) and Sat1 (SLC26A1) mediate sulfate (re)absorption across renal proximal tubule and small intestinal epithelia, thereby regulating blood sulfate levels. Disruption of murine NaS1 and Sat1 genes leads to hyposulfatemia and hypersulfaturia. Sat1-null mice also exhibit hyperoxalemia, hyperoxaluria, and calcium oxalate urolithiasis. This review will highlight the cu...

Crystallization of calcium sulfate dihydrate (CaSO4.2H2O) in sodium chloride solutions at different supersaturation (δ = 1.2–2), pH =3, ionic strength (I = 0.5 M) and at 80°C was studied. The influence of aluminum and magnesium nitrates having very low concentrations (10 mol dm) on the rate of crystallization at different supersaturation was investigated. The rate of crystallization was found t...

Secreted modular calcium-binding proteins 1 and 2 (SMOC-1 and SMOC-1) are extracellular calcium- binding proteins belonging to the BM-40 family of proteins. In this work we have identified a highly basic region in the extracellular calcium-binding (EC) domain of the SMOC-1 similar to other known glycosaminoglycan-binding motifs. Size-exclusion chromatography shows that full length SMOC-1 as wel...