BACKGROUND AND OBJECTIVES Continuous assessment of the cerebrovascular autoregulation (CVA) through use of the pressure reactivity index (PRx), a moving linear correlation coefficient between mean arterial blood pressure and intracranial pressure, has been effective in optimizing cerebral perfusion pressure (CPPopt) in traumatic brain injured (TBI) patients. This study investigates the feasibil...

Aneurysmal subarachnoid hemorrhage (SAH) affects 5-10 per 100,000 individuals per year1 and is associated with high rates of morbidity and mortality [1-4]. Main contributor to poor outcomes after SAH are the early cerebral injury (ECI) caused by the immediate increase in intracranial pressure, decreased cerebral perfusion pressure and global ischemia [1,5-9] and delayed cerebral ischemia (DCI) ...

Cerebral vasospasm is a major source of morbidity and mortality in patients with aneurysmal subarachnoid hemorrhage (aSAH). Evidence suggests a multifactorial etiology and this concept remains supported by the assortment of therapeutic modalities under investigation. The authors provide an updated review of the literature for previous and recent clinical trials evaluating medical treatments in ...

Vasospasm following traumatic brain injury (TBI) may dramatically affect the neurological and functional recovery of a vulnerable patient population. While the reported incidence of traumatic vasospasm ranges from 19%-68%, the true incidence remains unknown due to variability in protocols for its detection. Only 3.9%-16.6% of patients exhibit clinical deficits. Compared to vasospasm resulting f...

BACKGROUND AND PURPOSE Cerebral vasospasm (CV) with infarction causes a significant degree of morbidity and mortality after aneurysmal subarachnoid hemorrhage (aSAH). We sought to determine if reduced cerebral blood flow (CBF) on Xenon CT within 48 h of the ictus was predictive of developing CV with infarction. METHODS This is a prospective study from 1999 to 2006 of 97 patients with aSAH who...

PURPOSE Contrast-induced acute kidney injury (CI-AKI) is associated with poor outcomes after percutaneous coronary intervention. However, CI-AKI has rarely been evaluated within the neurovascular field. The aim of this study was to investigate the incidence and clinical implication of CI-AKI after coil embolization in patients with an aneurysmal subarachnoid hemorrhage (aSAH). MATERIALS AND M...

BACKGROUND Chronic shunt-dependent hydrocephalus is a complication of aneurysmal subarachnoid hemorrhage (aSAH). Its incidence and risk factors have been described while the hydrocephalus onset in terms of days after treatment (microsurgical or endovascular) has not been yet analyzed. MATERIALS AND METHODS 45 patients, treated for aSAH in 4 Italian Neurosurgical Departments, were retrospectiv...

Aneurysmal subarachnoid hemorrhage (SAH) affects 5-10 per 100,000 individuals per year1 and is associated with high rates of morbidity and mortality [1-4]. Main contributor to poor outcomes after SAH are the early cerebral injury (ECI) caused by the immediate increase in intracranial pressure, decreased cerebral perfusion pressure and global ischemia [1,5-9] and delayed cerebral ischemia (DCI) ...