A familial vulnerability to schizophrenia is agreed even though the exact genes involved seem elusive. But despite epidemiological evidence showing different rates of schizophrenia in sociocultural groups that would be considered genetically similar, the causal role of the environment is still hotly contested. Many service users, social scientists and clinicians are convinced that social factor...

Mitotic disjunction of the repetitive ribosomal DNA (rDNA) involves specialized segregation mechanisms dependent on the conserved phosphatase Cdc14. The reason behind this requirement is unknown. We show that rDNA segregation requires Cdc14 partly because of its physical length but most importantly because a fraction of ribosomal RNA (rRNA) genes are transcribed at very high rates. We show that...

Tasers are battery powered electrical devices used by law enforcement personnel to temporarily incapacitate a suspect. This study is a portion of a larger study to determine the probability of a Taser (X26 and M26) causing ventricular fibrillation (VF) in humans. We determined the distance between a Taser dart and the ventricle (dart-to-heart distance) necessary to trigger VF in an in-vivo porc...

Most beneficial and effective therapies also have the potential to cause harm. Cardiac resynchronization therapy (CRT) is now proven by large-scale clinical trials to be highly beneficial for chronic heart failure patients, with reduction in mortality and re-hospitalization, and improved quality of life. However, it does have potential adverse effects such as those associated with any pacemaker...

Five cases of ischaemic stroke preceded by minor head trauma in children are described. All patients had striatocapsular infarction. Three had no cerebrovascular abnormality; two had turbulent flow in the proximal middle cerebral artery. None of the patients had evidence of arterial dissection or any other risk factors for stroke. All made an excellent neurological recovery. Possible mechanisms...

T association of seizures with anesthetic agents has been a long debate and controversy for decades. There are several anesthetic agents that show seizure like activity after induction such as fentanyl, lignocaine, propofol, sevoflurane, and so forth. Among these agents, there are several reports of propofol, which is very frequently used as an anesthetic induction agent in India, and further a...

A familial vulnerability to schizophrenia is agreed even though the exact genes involved seem elusive. But despite epidemiological evidence showing different rates of schizophrenia in sociocultural groups that would be considered genetically similar, the causal role of the environment is still hotly contested. Many service users, social scientists and clinicians are convinced that social factor...

The use of statins may have unnatural effects. A 54-year-old woman was admitted to the hospital with an incidental finding of hypercalcemia (10.8 mg/dL). There was no disease other than hyperlipidemia, and the patient had been on a course of atorvastatin calcium 10 mg for 1.5 years. A workup investigation to diagnose the cause of hypercalcemia was completed. The investigation did not reveal any...