background: anxiety is the most prevalent psychological side effect of breast cancer and chemotherapy. this study aimed to determine the effect of slow stroke back massage (ssbm) on the anxiety of old female patients with breast cancer undergoing chemotherapy. methods: in this quasi-experimental study, 80 elderly women with breast cancer undergoing chemotherapy were enrolled by continuous sampl...

results the results showed that the mean scores of nausea in the control group was increased from 2.97 on the first day to 3.26 and in the intervention group was decreased from 3.44 to 1.52 at the end of trial. however there was not any significant difference in the first, second, third and fourth days between two groups. conclusions massage can reduce nausea. however further studies with large...

background cancer diagnosis among children can cause high stress and anxiety in parents, and they may lose their life expectancy. the present study investigated the effectiveness of logo therapy on anxiety and depression among mothers of children with cancer. materials and methods this study was conducted by a semi-pilot method using pre-test and post-test with a control experimental group. the...

receptors and proteins are overexpressed in many human cancer cell membranes rather than normal tissues and are considered as the main molecular targets. specific tumor- targeting molecules which have high affinity for these receptors can be valuable tools as carrier molecules for targeted cancer therapy and imaging. pharmacokinetics and bioavailability of diagnostic and therapeutic agents are ...

Mutational inactivation of p53 is a key player in the development of human cancer. Thus, retrieving the tumor suppressor activity of p53 gene is considered a novel strategy in cancer therapy. Current study aimed to investigate the anti-cancer potentials of botulinum toxin type-A (BTX-A) and captopril as a trial to shed light on effective anti-cancer therapy with lower side effects. Cytotoxic ef...

Abstract CRISPR-Cas9 viability screens are increasingly performed at a genome-wide scale across large panels of cell lines to identify new therapeutic targets for precision cancer therapy. Integrating the datasets resulting from these studies is necessary adequately represent heterogeneity human cancers and assemble comprehensive map genetic vulnerabilities. Here, we integrated two largest publ...

Abstract Receptor‐type protein tyrosine phosphatases (RPTPs), Class I phosphatases, are involved in human tumor cell proliferation, apoptosis, migration, and invasion through reversible phosphorylation of residues. This review summarizes the expression role RPTPs cancer illustrates signaling pathway mechanisms effecting oncogenesis, progression, prognosis, angiogenesis, so as to provide more ef...

Mutational inactivation of p53 is a key player in the development of human cancer. Thus, retrieving the tumor suppressor activity of p53 gene is considered a novel strategy in cancer therapy. Current study aimed to investigate the anti-cancer potentials of botulinum toxin type-A (BTX-A) and captopril as a trial to shed light on effective anti-cancer therapy with lower side effects. Cytotoxic ef...