Almost half of cancer patients experience cachexia syndrome. Cachexic patients are at risk of increased side effects of chemotherapy, reduced tolerance to chemotherapy drugs, longer duration of treatment period, and decreased quality of life. Cancer cachexia is a multifactorial syndrome. Micro ribonucleic acid (miRNA), a “non-coding RNA”, is considered to be a risk factor of cachexia and muscle...

breast cancer affects iranian women at least one decade younger than their counterparts in othercountries and the incidence of breast fibroadenoma is growing in the last two decades in tehran. thisstudy aimed to compare the ahr levels in premenopausal breast cancer and breast fibroadnemo withappropriate normal groups. possible associations of ahr with lifestyle and reproductive risk factorsand ...

background: exposure to endogenous hormones such as estrogen is known as a lifetime breast cancer (bc) risk factor. polymorphisms in genes that are involved in the steroidogenic process, such as cytochrome p450c17alpha ( cyp17) , affect individuals’ susceptibility to bc. in iran, the highest incident of bc is among young women. this study aimed to find prevalence of single nucleotide polymorphi...

background: several epidemiological studies suggest that tobacco smoking increases the risk of oral cancer. no systematic review, however, has been reported to examine how consistent the evidence is across the studies. we undertook a meta-analysis of epidemiological studies investigating the magnitude relationship between tobacco smoking and oral cancer. methods: primary studies were identified...

introduction: as one of the most common cancers among head and neck malignancies, cancer of the oral cavity probably has some variations in countries with a high prevalence of esophageal cancer.  materials and methods: patients with oral cavity cancer who were treated at two tertiary referral centers from january 1999 to january 2009 were included in this study. in addition to demographic data,...

background: breast cancer is the most common cancer and the leading cause of cancer death among the women worldwide. the risk of local and distant recurrence is the highest during the first two years following the initial treatment. very late relapse (after 12 years) is uncommon in breast cancer survivors. methods: herein, we report the characteristics and outcomes of 6 such cases of breast can...

Background: DNA methyltransferase-3B (DNMT3B) is an important enzyme responsible for maintaining the DNA methylation pattern in eukaryotic cells. In this study we have investigated the correlation between the 46359C→T polymorphism in the DNMT3B gene and the risk of breast cancer incidence among sporadic breast cancer patients in Fars Province, Southern Iran.Methods: In this case-control study, ...

Introduction: Breast cancer is the most common cancer and the leading cause of cancer-related death in women. Clinicopathological variables are important factors in deciding on breast cancer treatment. This study evaluated the association between the recurrence score generated by the Oncotype DX® 21-gene assay and classic clinicopathological variables. Methods: A single-institution retrospect...

ABSTRACT Background and Aim: Considering the increasing trend of thyroid cancer and increased number of new cases we performed this study to determine the risk factors for thyroid cancer in Kurdistan Province. Materials and Methods: 80 patients and 80 controls were matched and entered into this case-control study from September 2009 to September 2016 in Kurdistan Province. Data were colle...

background: in iran colorectal cancer (crc) incidence varies among various places. but we do not have any validate data that deeply explored the difference of crc in kerman province by national average. the aim of this study was to evaluate the incidence of colon cancer within a 12-year period in kerman province and to find whether the incidence of crc in kerman compared with the total incidenc...