he had used the tetrachloride of carbon instead of chloroform. The first patient got it undiluted, and during the first stage of the ansesthesia violent uterine action came on; but on pushing the action of the drug still further, the patient went off into a state of syncope. In this case he found it quite impossible to hit off the exact amount required so as to avoid excessive uterine action or...

The previously reported increases in liver and serum aspartate aminotransferase (ASAT) activities and liver protein content 24 hours after the administration of carbon tetrachloride (CCl4) were reduced by administering multiple doses of the protein synthesis inhibitor cycloheximide (CH). Liver ASAT and protein content were reduced to saline-injected control levels, and the serum ASAT increase w...

OBJECTIVE Recent studies show that free radicals are important mediators of hepatic injury induced by carbon tetrachloride. Allium (A.) paradoxum showed antioxidant and antihemolytic activities. This work was conduct to determine the possible protective effect of this plant against hepatotoxicity. MATERIALS AND METHODS Subcutaneous injection of 3 ml/kg carbon tetrachloride diluted in olive oi...

Pyruvate carboxylase (PC) has been quantified in rat liver and kidney cortex under experimental conditions that modify the gluconeogenic response in both organs: fasting, carbon tetrachloride-induced liver degeneration and alloxan-induced diabetes. Enzymatic activity has been assayed by a 14CO2-fixation method. The amount of enzyme has been determined by competitive ELISA using antibodies raise...

The changes in retinoid metabolism have been documented in liver cirrhosis. However, the dynamic alterations in levels of this vitamin between circulation and liver during development of the liver cirrhosis are not well understood. The aim of this study was to measure retinoids in the liver and circulation in parallel, during and after development of cirrhosis induced by carbon tetrachloride an...

In this study, we investigated the hepatoprotective effects of aged black garlic (ABG) in rodent models of liver injury. ABG inhibited carbon tetrachloride-induced elevation of aspartate transaminase (AST) and alanine transaminase (ALT), which are markers of hepatocellular damage, in SD rats. D-galactosamineinduced hepatocellular damage was also suppressed by ABG treatment. However, ABG does no...

The ability of high (6.73) and low (5.02) pH solutions of lead acetate precipitate of H. rosasinensis petal anthocyanin extract to prevent carbon tetrachloride (CCl4) induced lipid peroxidation in rats has been investigated using plasma malondialdehyde (MDA) level as an index of the process. Relative to its value in the plasma of CCl4 treated extract-free rats, the high pH form (pH 6.73; blue p...