نتایج جستجو برای: carbon vulcane xc 72
تعداد نتایج: 370920 فیلتر نتایج به سال:
C Maximum likelihood estimation C.1 Building the likelihoood function Let Θ = (Θ1; Θ2) = (σ , σ η, σ u, π; β1, λ1, β2, λ2, φ) be the vector of parameters. Let X = (x1,s,t, x2,s,t, r1,s,t, r2,s,t) be the vector of observables, with r2 = p2− p1 and r1 = p1. Let 1(x) be an indicator variable equal to 1 if the event x has occured, and 0 otherwise. Let g(x) be the standard normal PDF and G(x) the st...
Sepsis is the host's deleterious systemic inflammatory response to microbial infections. Here we report an essential role for the estrogen sulfotransferase (EST or SULT1E1), a conjugating enzyme that sulfonates and deactivates estrogens, in sepsis response. Both the cecal ligation and puncture (CLP) and lipopolysacharide (LPS) models of sepsis induce the expression of EST and compromise the act...
AIMS Phosphoinositide 3-kinases (PI3Ks) relay growth factor signaling and mediate cytoprotection and cell growth. The cystine/glutamate antiporter system xc(-) imports cystine while exporting glutamate, thereby promoting glutathione synthesis while increasing extracellular cerebral glutamate. The aim of this study was to analyze the pathway through which growth factor and PI3K signaling induce ...
This paper sets out our observations, modeling results, and conclusions regarding a novel organizational form applied variously as “extreme collaboration” (XC) or “radical collocation.” XC teams are cross-functional, co-located groups enabled with high-performance computer modeling and simulation tools, large interactive graphic displays, a mature shared generic project model that the design te...
As noted by Warburg, many cancer cells depend on the consumption of glucose. We performed a genetic screen to identify factors responsible for glucose addiction and recovered the two subunits of the xCT antiporter (system xc-), which plays an antioxidant role by exporting glutamate for cystine. Disruption of the xCT antiporter greatly improves cell viability after glucose withdrawal, because co...
Cold environments are common throughout the Galaxy. We are conducting a series of experiments designed to probe the low-temperature limits for growth in selected methanogenic and halophilic Archaea. This paper presents initial results for two mesophiles, a methanogen, Methanosarcina acetivorans, and a halophile, Halobacterium sp. NRC-1, and for two Antarctic coldadapted Archaea, a methanogen, M...
This paper sets out our observations, modeling results, and conclusions regarding a novel organizational form applied variously as “Extreme Collaboration” (XC) or “radical collocation.” XC teams are cross-functional, co-located groups enabled with high-performance computer modeling and simulation tools, large interactive graphic displays, a mature shared generic project model that the design te...
During tumorigenesis, the high metabolic demand of cancer cells results in increased production of reactive oxygen species. To maintain oxidative homeostasis, tumor cells increase their antioxidant production through hyperactivation of the NRF2 pathway, which promotes tumor cell growth. Despite the extensive characterization of NRF2-driven metabolic rewiring, little is known about the metabolic...
BACKGROUND The chemical reaction of carbon dioxide absorbent and sevoflurane is known to produce compound A. However, carbon dioxide absorbents are not controlled by the Food and Drug Administration, but are treated as industrial products in some nations. Moreover, carbon dioxide absorbents differ in their capacities to produce compound A, because their chemical compositions differ. In this stu...
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