Incidence rates for adenocarcinoma of the esophagus and gastric cardia have been rising rapidly. We examined nutrient intake as a risk factor for esophageal and gastric cancers in a population-based case-control study in Connecticut, New Jersey, and western Washington state. Interviews were completed for cases with histologically confirmed esophageal adenocarcinoma (n = 282), adenocarcinoma of ...

The results of two epidemiological studies suggest that high intake of heterocyclic amines, which are formed on the surface of meats cooked at high temperatures, might be associated with increased risk of esophageal or cardia cancers. Our aim was to further investigate heterocyclic amine intake and risk of these cancers. We examined data from a nationwide, population-based, case-control study o...

Heartburn is a common symptom affecting 21-44% of the adult population on a monthly basis. Oesophagitis is less common, affecting 2% of individuals. Epidemiological studies have shown that patients with gastro-oesophageal reflux disease (GORD) have similar incidence rates of Helicobacter pylori infection as do controls. Some groups have reported that there is a lower incidence, deducing that in...

BACKGROUND There had never been a clear definition of the cancer of cardia before Siewert's classification, which was proposed in 1996 and approved in 1997 at the second International Gastric Cancer Congress in Munich. On the basis of the classification, this study aims to research into the clinicopathological characteristics and surgical modes of adenocarcinoma of the esophagogastric junction ...

OBJECTIVES To assess the association of H. pylori and chronic atrophic gastritis (AG) with colonic, pancreatic and gastric cancer in a population-based prospective cohort. METHODS Serum antibodies against H. pylori in general and specific to cytotoxin-associated gene A (CagA), as well as serum pepsinogen I and II were analyzed in 9,506 men and women, aged 50-75 years in a cohort study from Sa...

Gastric cancer, the second most common cause of cancer-related death in the world, is characterized as a multifactorial disease that results from individual genetic predisposition and exposure to environmental factors (Brenner et al., 2009). According to anatomic site, gastric cancer can be classified as cardia and non-cardia subtypes. In non-cardia gastric cancer, Helicobacter pylori (H. pylor...

Background: Proximal gastrectomy is a rarely performed procedure but feasible option in benign tumors and malignant neoplasms the proximal third of stomach since novel options reconstructions are available nowadays with fewer long-term sequels. Methods: Report three cases gastric gastrointestinal stromal (GIST), description its presentation, histological characteristics, follow-up after being t...

Esophageal achalasia is a neuromuscular disorder of unknown etiology characterized by abnormal motility and failure of relaxation of lower esophageal sphincter, with its usual presentation in fourth and fifth decades of life. It is an unusual lesion in childhood and extremely rare under the age of one year. We report a 7-month-old child with esophageal achalasia treated with modified Heller's e...