3. Patients with a suspected acute coronary syndrome should be observed, with repeat 12 lead ECG recording, during symptoms if the opportunity arises. Blood samples for cardiac troponin (troponin T or I) should be taken a minimum of 12 hours after the onset of symptoms. New ischaemic changes on the ECG or elevation of troponin confirm the diagnosis (see table 1 and recommendation 5). A 4. If at...

3. Patients with a suspected acute coronary syndrome should be observed, with repeat 12 lead ECG recording, during symptoms if the opportunity arises. Blood samples for cardiac troponin (troponin T or I) should be taken a minimum of 12 hours after the onset of symptoms. New ischaemic changes on the ECG or elevation of troponin confirm the diagnosis (see table 1 and recommendation 5). A 4. If at...

The quest for a test that is absolutely disease-and tissue-specific could be considered the Holy Grail of the clinical chemist, dreamt of but seldom achieved. Initial reports on measurement of the cardiac troponins, cardiac troponin T (cTnT) and cardiac troponin I (cTnI), for diagnosis of myocardial infarction suggested that these markers would become the " gold standard, " replacing all other ...

Troponin, an important regulatory protein of the thin filament (actin) of striated muscle, is a complex of 3 subunits: C, T, and I. Troponin T and I isoforms from the heart are structurally different from the corresponding forms found in skeletal muscle. Because of this distribution, the measurement of cardiac troponin T and I isoforms is superior to other serum biomarkers of cardiac disease su...

BACKGROUND Thin filament mutations are reported to cause approximately 20% of cases of hypertrophic cardiomyopathy (HCM), and they have been associated with specific phenotypes. However, the frequency of these mutations and their associated phenotype(s) from a large tertiary referral center population are unknown. METHODS AND RESULTS DNA was obtained from 389 unrelated patients with HCM. A mu...

Striated muscle contraction is regulated by the binding of Ca(2+) to the N-terminal regulatory lobe of the cardiac troponin C (cTnC) subunit in the troponin complex. In the heart, beta-adrenergic stimulation induces protein kinase A phosphorylation of cardiac troponin I (cTnI) at Ser23/24 to alter the interaction of cTnI with cTnC in the troponin complex and is critical to the regulation of car...

Background Elective open heart surgery is associated with troponin release in some cases due to myocyte necrosis. Objectives The aim of this study was to measure cardiac troponin I (cTnI) preoperatively in elective CABG after remote ischemic preconditioning. Methods Twenty-eight patients were selected for elective CABG. They were randomized to receive remote ischemic preconditioning (induce...

INTRODUCTION Cardiac troponin has been shown to be elevated in one-half of the parturients admitted for post-partum haemorrhage. The purpose of the study was to assess whether increased cardiac troponin was associated with a simultaneous alteration in haemoglobin tissue oxygen saturation in peripheral muscles in post-partum haemorrhage. METHODS Tissue haemoglobin oxygen saturation of thenar e...