How specific cargo recognition by coat proteins is achieved and how this recognition event may regulate vesicle formation are still under investigation. In two recent papers by the Owen and Goldberg labs, the binding mode of dilysine motifs to the coatomer of the COPI coat has been analysed. Collectively, their findings suggest that the dilysine motif containing cargo proteins may stabilize coa...

Speed economy, proposed by Japanese scholars Masaki Tamura, refers to get the cost savings flow by accelerating the transaction process [1], which brings the a large market space to the cargo/express delivery industry [2]. Due to the rapidly growth of China air cargo/express market and the ongoing increasingly opening up of the sky, international cargo/express giants have set up their hubs in C...

Seaports function as lifeline systems in maritime transportation, facilitating critical processes like shipping, distribution, and allied cargo handling. These diverse subsystems constitute the Port Infrastructure System (PIS) have intricate functional interdependencies. The PIS is vulnerable to several external disruptions, impact of COVID-19 severe unprecedented this domain. Therefore, study ...

This investigation has been carried out under a contract awarded by the Netherlands Directorate-General of Civil Aviation (RLD), contract number LI/99.121/2. Summary Previous research has suggested that cargo operators suffer a disproportionally high number of accidents. The degree of unsafety could however not properly be quantified due to lack of data. The objective of the underlying study wa...

Thrombospondins (TSPs) are an evolutionarily ancient family of extracellular calcium-binding glycoproteins. The five mammalian TSPs collectively have important roles in angiogenesis and vascular biology, synaptogenesis, wound repair and connective tissue organisation. Their complex functions relate to the multiple postsecretion fates of TSPs that can involve endocytic uptake, proteolysis or ret...

Autophagy is a major pathway for the clearance of harmful material from the cytoplasm. During autophagy, cytoplasmic material is delivered into the lysosomal system by organelles called autophagosomes. Autophagosomes form in a de novo manner and, in the course of their formation, isolate cargo material from the rest of the cytoplasm. Cargo specificity is conferred by autophagic cargo receptors ...

The article highlights the experience of design and construction with expansion existing airports, considers factors that shape development trends modern international airports. Some general principles methods airports are revealed. formation is influenced by many factors, primarily socio-economic in air transport. In last 20, 30 years, largest percentage world's reconstruction mandatory Thus, ...

Vesicular transport of cellular cargo requires targeted membrane fusion and formation of a SNARE protein complex that draws the two apposing fusing membranes together. Insulin-regulated delivery and fusion of glucose transporter-4 storage vesicles at the cell surface is dependent on two key proteins: the SNARE integral membrane protein Syntaxin4 (Sx4) and the soluble regulatory protein Munc18c....