Two major forms of human carboxylesterase (CES), CES1A and CES2, dominate the pharmacokinetics of most prodrugs such as imidapril and irinotecan (CPT-11). Excipients, largely used as insert vehicles in formulation, have been recently reported to affect drug enzyme activity. The influence of excipients on the activity of CES remains undefined. In this study, the inhibitory effects of 25 excipien...

in enzymatic content of the cells. Throughout the course of this study, grading of the amount of growth by visual estimation has been a routine observation. Once a certain minimum amount of mycelium was present there did not seem to be an apparent correlation between the amount of growth and the yield of the desired steroids. In the experiments where dextrin replaced sucrose as the carbohydrate...

dracocephalum kotschyi boiss, a member of labiatae family, is a native plant to iran, which has been reported to have immunomodulatory, antihyperlipidemic and antispasmodic activities. the objective of this research was to study the antispasmodic and antidiarrhoeal activities of hydroalcoholic and hexane extracts of d. kotschyi in mice. furthermore, the antidiarrhoeal and antispasmodic effect o...

All the cultivated Brassica species exhibited powdery mildew severity with highest (43.2%) on juncea followed by B. rapa (28.0%) which is widely in India. Yield losses from 10-90 per cent reduction 6.47 oil content have been estimated different species. Hence, present study was carried out to evaluate oils manage disease and aphids an organically grown mustard crop. Five (castor, groundnut, sun...

The purpose of the study was to evaluate the suitability of laboratory scale spheronizer for the production of spherical pellets loaded with diltiazem hydrochloride by wax combination. The 1:1 combination of cetyl alcohol and hydrogenated castor oil, as low and high melting point waxes, were used. The various production variables affecting the different characteristics of pellets and the proces...