نتایج جستجو برای: castrated mice
تعداد نتایج: 394807 فیلتر نتایج به سال:
PTHrP is the major pathogenetic factor for hypercalcemia in several malignancies including prostate cancer. In the current study, we have assessed the ability of androgens to regulate PTHrP production in androgen-insensitive human prostate cancer cells PC-3 and cells transfected with androgen receptor (PC-3T). Androgen responsiveness caused a marked decrease in PC-3T cell growth, and treatment ...
The formation of tumors in intrasplenic ovarian grafts in castrated hosts has been observed re peatedly in rats (1, 10) and mice (2, 7, 8, 9). In all the studies undertaken up to this time both young hosts and donors were used; in fact, autologous grafts have been made in most of the experiments. The theory has been proposed that ovarian tumorigcnesis occurs in the intrasplenic and intrapancrea...
there are many discrepancies around the effect of sex hormones on spatial learning and memory in rodents. the aim of the present study was to investigate the effects of chronic administration of estradiol (es) and testosterone (tes) on spatial memory in adult castrated male rats. cholinesterase activity of the hippocampus in treated animals was also measured to seek if hormonal treatment can ch...
Young intact (18 days old) and adult castrated males of CBA and C3H/Di mice were used for measuring the estrogenicity on the basis of growth response of mammary epithelial structures and the weight of seminal vesicles. It was demonstrated that heavier young males had disproportionally heavier seminal vesicles (sex steroid-responsive organs) than small animals at day 33 of age (that is on the da...
Although androgen ablation therapy is effective in treating primary prostate cancers, a significant number of patients develop incurable castration-resistant disease. Recent studies have suggested a potential synergy between vaccination and androgen ablation, yet the enhanced T-cell function is transient. Using a defined tumor antigen model, UV-8101-RE, we found that concomitant castration sign...
The results of several investigations1-5 have suggested that nucleic acids play a role in mediating the anabolic action of androgens. RNA extracted from prostatic nuclei of androgen-treated castrates enhanced the incorporation of amino acids into protein in a bacterial ribosomal system.6 An RNA preparation from the uteri of estrogen-treated rats induced morphologic changes resembling those prod...
Metabolomics has opened new possibilities to investigate metabolic differences among animals. In this study, we applied a targeted metabolomic approach to deconstruct the pig sex metabolome as defined by castrated males and entire gilts. Plasma from 545 performance-tested Italian Large White pigs (172 castrated males and 373 females) sampled at about 160 kg live weight were analyzed for 186 met...
The transcriptional coactivator SRC-3 plays a key role in enhancing prostate cancer cell proliferation. Although SRC-3 is highly expressed in advanced prostate cancer, its role in castration-resistant prostate cancer (CRPC) driven by PTEN mutation is unknown. We documented elevated SRC-3 in human CRPC and in PTEN-negative human prostate cancer. Patients with high SRC-3 and undetectable PTEN exh...
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