Application of isonicotinic acid hydrazide and related compounds under the name Rimifon, Nicotibine, Tizide, Ditubine, was carried out in a total number of 160 cases in the University Clinic of Phthisiology of Athens at the Sanatorium “Sotiria”. The present study concerns only 36 cases of pulmonary tuberculosis of which four had tuberculous laryngitis. The limited number of 36 selected cases ou...

Purpose: Smear scores and induration sizes resulting from the PPD (tuberculin purified protein derivative) test can serve as indicators of whether a patient suffering from tuberculosis shows smear conversion or not. Methods: Using microbiological methods smear and sputum tests, patients diagnosed as infected with Mycobacterium tuberculosis between 2002 and 2015 were included in this study. All ...

The molecular determinants of the immune response to Mycobacterium tuberculosis HN878 infection in a rabbit model of pulmonary cavitary tuberculosis were studied. Aerosol infection of rabbits resulted in a highly differentially expressed global transcriptome in the lungs at 2 weeks, which dropped at 4 weeks and then gradually increased. While IFNγ was progressively upregulated throughout the in...

The aim of this study was to analyze all new pulmonary tuberculosis cases and to assess the frequency and consequences of associated diabetes mellitus. Although apparently distinct, these two diseases could be linked, as suspected since decades. The context is the persistent endemicity of tuberculosis and the recent emergence of diabetes, two major health events for developing countries. The st...

tion of a pigmented neuroendocrine tumor. Arch Ophthalmol. 2000;118(6):841-845. 6. Mashayekhi A, Shields CL, Eagle RC Jr, Shields JA. Cavitary changes in retinoblastoma: relationship to chemoresistance. Ophthalmology. 2005;112(6):1145-1150. 7. Lois N, Shields CL, Shields JA, Eagle RC Jr, De Potter P. Cavitary melanoma of the ciliary body: a study of eight cases. Ophthalmology. 1998; 105(6):1091...

Cavitary lung lesions of various etiologies may be encountered in patients with respiratory symptoms associated with fever. Non-malignant cavitary lesions may mimic malignant lung lesions on most of radiographic modalities including chest radiographs or thoracic computed tomography (CT). Primary lung malignancy can be detected in as high as one-fifths of CT thorax as cavitary lesions and the re...

Improved knowledge regarding the tissue penetration of antituberculosis drugs may help optimize drug management. Patients with drug-resistant pulmonary tuberculosis undergoing adjunctive surgery were enrolled. Serial serum samples were collected, and microdialysis was performed using ex vivo lung tissue to measure pyrazinamide concentrations. Among 10 patients, the median pyrazinamide dose was ...

BACKGROUND Although resistance to isoniazid (INH) is the most common form of drug resistance seen among Mycobacterium tuberculosis isolates, there have been few studies on the efficacy and optimal duration of treatment for patients with INH-resistant tuberculosis (TB). METHODS We evaluated retrospectively the treatment outcomes of 39 patients who were treated for INH-resistant pulmonary TB. T...

Healio.com/Pediatrics | 139 Editor’s note: Each month, this department features a discussion of an unusual diagnosis in areas including genetics, radiology, or dermatology. A description and images are presented, followed by the diagnosis and an explanation of how the diagnosis was determined. As always, your comments are welcome via email at [email protected]. A4-month-old boy was referred to ...

We read with great interest the well-written article by Tseng and Chen, 1 who described the case of a 65-year-old woman who presented with hemoptysis and a cavitary lesion in the right lung with an air crescent sign and an intracavitary fungus ball-like mass. The final diagnosis was lung carcinoma. The authors highlighted the importance of cavity wall thickness for the differential diagnosis, r...