c-Type cytochromes are located partially or completely in the periplasm of gram-negative bacteria, and the heme prosthetic group is covalently bound to the protein. The cytochrome c maturation (Ccm) multiprotein system is required for transport of heme to the periplasm and its covalent linkage to the peptide. Other cytochromes and hemoglobins contain a noncovalently bound heme and do not requir...

The unicellular green alga Chlamydomonas reinhardtii is a long-established model organism for studies on photosynthesis and carbon metabolism-related physiology. Under conditions of air-level carbon dioxide concentration [CO2], a carbon concentrating mechanism (CCM) is induced to facilitate cellular carbon uptake. CCM increases the availability of carbon dioxide at the site of cellular carbon f...

BACKGROUND There is evidence to suggest that frontline community health workers in Malawi are under-referring children to higher-level facilities. Integrating a digitized version of paper-based methods of Community Case Management (CCM) could strengthen delivery, increasing urgent referral rates and preventing unnecessary re-consultations and hospital admissions. This trial aims to evaluate the...

BACKGROUND A recent systematic review suggests that practice facilitation (PF) is a robust intervention for implementing evidence-based preventive care guidelines in primary care, but the ability of PF to improve chronic illness care remains unclear. AIMS To examine the specific activities and Chronic Care model (CCM) components that primary care practices implemented and sustained in respons...

The antimicrobial activity of fatty acids, monolaurin, citric, succinic, fumaric, malic and lactic acid was determined in cultures of two strains of Escherichia coli, three strains of Salmonella sp. and two strains of Clostridium perfringens. Antimicrobial activity was expressed as minimum inhibitory concentration (MIC) that prevented growth and glucose utilization in treated cultures. Caprylic...

BACKGROUND AND PURPOSE We sought to compare the effect of chronic treatment with commonly tolerated doses of Fasudil, a specific RhoA kinase (ROCK) inhibitor, and simvastatin (with pleiotropic effects including ROCK inhibition) on cerebral cavernous malformation (CCM) genesis and maturation in 2 models that recapitulate the human disease. METHODS Two heterozygous murine models, Ccm1+/-Msh2-/-...

In this paper, a non-probabilistic Chebyshev convex method (CCM) for the transient dynamics of dual-disk rotor system with uncertain parameters is proposed. The dynamic equation derived by finite element (FEM), and deterministic response obtained. Then CCM used to obtain responses system. amplitude ranges characteristics are quite close calculation results Monte Carlo simulation (CMCS), which v...

OBJECTIVES The aims of this study were to investigate and validate quantitative susceptibility mapping (QSM) for lesional iron quantification in cerebral cavernous malformations (CCMs). MATERIALS AND METHODS Magnetic resonance imaging studies were performed in phantoms and 16 patients on a 3-T scanner. Susceptibility weighted imaging, QSM, and R2* maps were reconstructed from in vivo data acq...

JHDL is a design tool for reconfigurable systems that allows designers to express circuit organizations that dynamically change over time in a natural way, using only standard programming abstractions found in objectoriented languages. JHDL manages FPGA resources in a manner that is similar to the way object-oriented languages manage memory: circuits are treated as distinct objects and a circui...

Commercial off-the-shelf (COTS) middleware is increasingly used to develop distributed real-time and embedded (DRE) systems. DRE systems are increasingly combined using wireless and wireline networks to form “systems of systems” having multiple quality of service (QoS) requirements. Conventional COTS middleware does not facilitate the separation of QoS policies from application functionality, m...