Purpose To evaluate the ability of a targeted genome-wide association study (GWAS) to identify genes associated with central corneal thickness (CCT). Methods A targeted GWAS was used to investigate whether ten candidate genes with known roles in corneal development were associated with CCT in two Singaporean populations. The single nucleotide polymorphisms (SNPs) within a 500 kb interval enco...

We sought to evaluate central corneal thickness (CCT), corneal endothelial cell density (ECD) and intraocular pressure (IOP) in patients with type 2 diabetes mellitus (DM) and to associate potential differences with diabetes duration and treatment modality in a prospective, randomized study. We measured ECD, CCT and IOP of 125 patients with type 2 DM (mean age 57.1±11.5 years) and compared them...

BACKGROUND/AIMS To preliminarily evaluate the repeatability of central corneal thickness (CCT) measurements performed with Anterior Segment Optical Coherence Tomography (AS-OCT) on eye bank posterior corneal lenticules. METHODS Six donor lenticules were created with a 350 μm head microkeratome (Moria, Antony, France). All donor tissues were stored at 4°C in Eusol-C solution (Alchimia S.r.l, P...

purpose: to assess the agreement of ultrasonic pachymetry, the galilei dual scheimpflug analyzer and orbscan ii in measuring central corneal thickness (cct) in normal and keratoconic eyes. methods: in this prospective comparative study, cct was measured in 88 refractive surgery candidates and 76 (39 right) eyes of 45 keratoconic patients using ultrasonic pachymetry, galilei and orbscanii. readi...

were: infection 9 (14%), accident 6 (9%), other 6 (9%), not known 5 (8%), malignancy 4 (6%), liver disease 3 (5%). Within the Birth Cohort, 18 (6%) patients died, 7 from cardiac causes. Three-hundred and four (55.9%) patients switched to CCT and 269 (49.4%) continued for at least six months. Indications for switching were: high serum ferritin (66.6%), deteriorating left ventricular function on ...

In the present study, treatment of HEK-293 cells with the synthetic small molecule N-iodoacetyl-tryptophan (I-Trp) at submicromolar concentrations efficiently induced cell apoptosis as judged from the accumulation of sub-G(0) cells and intracellular DNA fragmentation. Activation of all intracellular caspases, except caspase-1, was detected in I-Trp-treated cells. Proteomic analysis revealed tha...

This paper presents a linear approximation method to determine the probability density function (PDF) of the critical clearing time (CCT) and probability of stability for a given disturbance in power system transient stability analysis. The CCT is the maximum time interval by which the fault must be cleared in order to preserve the system stability. The CCT depends on the system load level and ...

Purpose. To analyse the diurnal variation of central choroidal thickness (CCT) in healthy emetropic patients during working hours. Methods. Fifty healthy young emmetrpic volunteers were included in this study. CCT was measured at 9 AM and 4 PM with spectral domain optical coherence tomography (Spectralis, Heidelberg Engineering) with enhanced depth imaging. Diurnal variation of CCT, the correla...

Purpose. To compare central corneal thickness (CCT) values via Spectral Domain-Optical Coherence Tomography (SD-OCT) and ultrasonic pachymetry in patients with severe dry eye disease (DED) to determine the level of agreement between these 2 methods. Methods. The paired samples t-test was used to compare CCT values in severe DED patients. Matching analysis between methods was performed using int...

AIM To compare central corneal thickness (CCT) and anterior chamber depth (ACD) measurements using rotating Scheimpflug imaging and partial coherence interferometry. METHODS As part of the first phase of Shahroud Eye Cohort Study with 5 190 subjects of 40 to 64 years of age, CCT and ACD were measured using Scheimpflug imaging with the Pentacam (Oculus, Inc., Lynnwood, WA, USA) and partial coh...