Acute myeloid leukemias (AMLs) with a rearrangement of the mixed-linage leukemia (MLL) gene are aggressive hematopoietic malignancies. Here, we explored the feasibility of using the H3K9- and H3K36-specific demethylases Jmjd2/Kdm4 as putative drug targets in MLL-AF9 translocated leukemia. Using Jmjd2a, Jmjd2b, and Jmjd2c conditional triple-knockout mice, we show that Jmjd2/Kdm4 activities are r...

<b>Introduction: </b>B-acute lymphoblastic leukemia (B-ALL) is a malignant neoplasm of hematopoietic stem cells originating in bone marrow and characterized by proliferation blast lymphoid series. The aim this study was to predictive scoring system (SS) using fully standardized EuroFlow eight-color panel.<br /> <b>Methods:</b> expression the different cluster diffe...