Targeting the cell cycle is an attractive anticancer strategy, as its dysregulation is a common, if not ubiquitous, occurrence in tumour development. Cell-cycle control is achieved by the interaction of a complex set of enzymes and other proteins, including the family of protein kinases known as cyclin-dependent kinases (CDKs) and the protein product of the tumour suppressor gene Retinoblastoma...

Cyclin-dependant kinases play a central role in coordinating cell growth and division, and in sustaining proliferation of cancer cells, thereby constituting attractive pharmacological targets. However, there are no direct means of assessing their relative abundance in living cells, current approaches being limited to antigenic and proteomic analysis of fixed cells. In order to probe the relativ...

The cell cycle of mammalian cells is divided into four phases: G1 (first gap), S (DNA synthesis), G2 (second gap), and M (mitosis). Quiescent cells that have not entered the cell cycle are referred to as being in G0. Progression through the cell cycle requires the activation of cyclindependent kinases (CDKs). CDK activation is dependent on the association of the CDK with a cyclin regulatory sub...

The adoption of new treatment modalities remains crucial as lung cancer has one the lowest survival rates, along with liver and pancreatic cancer. Bortezomib is a proteasome inhibitor that higher anticancer effect in combination therapies. Therefore, aim this study to investigate whether bortezomib could have additional when combined cyclin-dependent kinase (CDK) inhibitor-roscovitine vitro. Ap...

Recently, multitargeted drugs are considered a potential approach in treating cancer. In this study, twelve in-house indole-based derivatives were preliminary evaluated for their inhibitory activities over VEGFR-2, CDK-1/cyclin B and HER-2. Compound 15l showed the most among tested was its selectivity small kinase panel. It dual Moreover, vitro cytotoxicity assay assessed selected series agains...

Degenerative disease is a non-communicable that arises from an unhealthy lifestyle, so it can reduce the physical and mental quality of sufferer. Chronic Kidney Disease (CDK) degenerative included in world's top 10 causes death according to World Health Organization (WHO). This study used CDK data with attributes age, blood pressure, weight, albumin levels, sugar red cells, pus cell clots, bact...

Several observations indicate that late-G1/S-phase-specific cellular functions may be required for herpes simplex virus (HSV) replication: (i) certain mutant HSV strains are replication impaired during infection of cells in the G0/G1 but not in the G1/S phase of the cell cycle, (ii) several late-G1/S-phase-specific cellular proteins and functions are induced during infection, and (iii) the acti...