BACKGROUNDS Over 50% of antibiotics prescriptions are for outpatients with acute respiratory infections (ARI). Many of them are not needed and thus contribute both avoidable adverse events and pressures toward the development of bacterial resistance. Could a clinical decision support system (CDSS), interposed at the time of electronic prescription, adjust antibiotics utilization toward consensu...

We used principal component analysis to develop measures (called Z-parameters in this study) which reflect the diversity of codon usage in Escherichia coli genes. Protein production levels for 1500 CDSs (protein-coding sequences) identified by E.coli genome projects in Japan and the US were estimated from a correlation equation between Z1 and cellular protein content obtained through analysis o...

Credit risk modeling is about modeling losses. These losses are typically coming unexpectedly and triggered by shocks. So any process modeling the stochastic nature of losses should reasonable include jumps. In this paper we review a few jump driven models for the valuation of CDSs and show how under these dynamic models also pricing of (exotic) derivatives on single name CDSs is possible. More...

Nurse clinicians need to make complex decisions on a continual basis, while delivering costeffective treatments. The rapid proliferation of medical and nursing knowledge complicates the decision-making process, particularly for novice nurses. We describe a Clinical Decision Support System (CDSS) for the novice nurse that combines evidence-based nursing knowledge with specific patient informatio...

the issue of medical errors is currently a global concern which places a heavy financial and emotional burden on communities. a clinical decision support system (cdss) is an electronic system designed to support clinical decision making. considering the increasing importance and use of systematized nomenclature of medicine-clinical terms (snomed-ct), we developed snomed-ct to implement it more ...

BACKGROUND Analysis of the evolutionary dynamics of Helicobacter pylori allowed tracing the spread of infection through populations on different continents but transmission pathways between individual humans have not been clearly described. MATERIALS AND METHODS To investigate person-to-person transmission, we studied three families each including one child with persistence of symptoms after ...

COLLABORATIVE DATA SHARING WITH MAPPINGS AND PROVENANCE Todd J. Green Supervisors: Zachary G. Ives and Val Tannen A key challenge in science today involves integrating data from databases managed by different collaborating scientists. In this dissertation, we develop the foundations and applications of collaborative data sharing systems (CDSSs), which address this challenge. A CDSS allows colla...