Carbohydrate-deficient transferrin (CDT) is a useful indicator of excessive alcohol consumption with higher sensitivity and specificity than other markers that are used. In the present study, CDT was analysed in 161 patients hospitalized in a surgical ward to evaluate whether history of drinking and chronic alcohol misuse are important determinants of CDT elevations. Fifty-one of the patients w...

OBJECTIVE To investigate the effects of number of channels and speech-to-noise ratio on connected discourse tracking (CDT) through simulations of cochlear implant speech processing. Previous studies have used citation-form vowel and consonant materials or simple sentences. CDT rates were expected to be less likely to be limited by ceiling effects and more representative of everyday speech commu...

BACKGROUND The role of carbohydrate-deficient transferrin (CDT) as a reliable marker for the detection of chronic alcohol abuse has been discussed controversially. METHODS Therefore, we investigated CDT in the sera from 405 subjects with different alcohol intake. Besides healthy control subjects (n = 42), inpatients and outpatients in a department of gastroenterology (n = 325) and patients ad...

BACKGROUND Carbohydrate-deficient transferrin (CDT) is a useful biomarker to identify excessive alcohol consumption; however, few studies have validated the %CDT cut-off value in elderly men. This study estimated the optimal %CDT cut-off value that could identify excessive alcohol consumption in men aged ≥65 years. METHODS This retrospective study included 120 men who visited the department o...

The authors studied the validity of the Clock-Drawing Test (CDT) in comparison with the Mini-Mental State Examination (MMSE) and the association between the CDT and mortality in a large general population sample of persons aged 75 years or more. Data were obtained from the MRC Trial of the Assessment and Management of Older People in the Community. Baseline assessments were conducted between 19...

Cytolethal distending toxin (CDT) is a secreted tripartite genotoxin produced by many pathogenic gram-negative bacteria. It is composed of three subunits, CdtA, CdtB and CdtC, and CdtB-associated deoxyribonuclease (DNase) activity is essential for the CDT toxicity. In the present study, to design a novel potentially antitumor drug against lung cancer, the possible mechanisms of cdtB anticancer ...

When expressed in Saccharomyces cerevisiae using either of two constitutive yeast promoters (PGK1prom and CCW12prom), the transporters CDT-1 and CDT-2 from the filamentous fungus Neurospora crassa are able to catalyze, respectively, active transport and facilitated diffusion of cellobiose (and, for CDT-2, also xylan and its derivatives). In S. cerevisiae, endogenous permeases are removed from t...

This work focuses on the newly discovered bifurcation phase transition of CDT quantum gravity. We define various order parameters and investigate which is most suitable to study this transition in numerical simulations. By analyzing the behaviour of the order parameters we present evidence that the transition separating the bifurcation phase and the physical phase of CDT is likely a second or h...

AIMS Blood pressure (BP) changes in alcohol-dependent individuals during a 12-week alcohol relapse prevention study were examined in light of drinking status and biomarkers of alcohol consumption [carbohydrate-deficient transferrin (%CDT) and gamma-glutamyl transpeptidase (GGT)]. METHODS Of 160 randomized alcoholic individuals, 120 who had hypertension and in whom daily drinking data was avai...

Diagnostic accuracy of a computer assisted diagnostic system compared to conventional markers of alcoholism. Netherlands (van Lambalgen, professor of logic and artificial intelligence). Acknowledgements All laboratory tests, except carbohydrate-deficient transferrin (CDT) were performed in the ABSTRACT Context Conventional tests for alcoholism have good screening properties for detecting hazard...