the diagnosis of celiac disease (cd) relies on the concordance of pathological, serological, genetic and clinical features. for this reason, the diagnosis of cd is often a challenge. seronegative celiac disease (sncd) is defined by the negativity of anti-tissue transglutaminase antibodies in the presence of a positive histology on duodenal biopsy samples, i. e. inflammatory infiltrate of intra-...

Celiakia represents a prototype of chronic antigenic stimulation and autoimmune dysregulation leading to the accumulation of reactive cytotoxic intraepithelial lymphocytes (IEL) and small intestinal mucosal injury. These lymphocytes possess a potential of transformation, gaining an aberrant phenotype and genotype during their clonal expansion. The development of type I enteropathy –associated T...

We report two cases of a man and a woman whose association of Crohn’s disease (CRD) and celiac disease (CD) was evident and significant. The characteristic of our patients was the young age of discovery, and the localization of the CRD which was different in the two cases: colic localization in the woman and ileal stenosing in the man. The diagnosis of MCO was confirmed by the histological stud...

Adherence to a restrictive gluten-free diet is the only known treatment for celiac disease (CD). Children and adolescents with CD encounter challenges while managing the diet in daily activities. Understanding their participation characteristics is lacking. The aim was to describe the development and validation process of the Celiac Disease-Children's Activities Report (CD-Chart). The final CD-...

OBJECTIVES To study bone mineral density (BMD) and standard serum biochemical indices among newly diagnosed and already diagnosed cases of Celiac Disease (CD) on gluten free diet for at least one year. METHODS This hospital based analytic, observational study was done at a tertiary care centre, from April 2013 through June 2014. Thirty six children (20 females) with untreated CD at diagnosis ...

celiac disease (cd) is a rare malabsorption syndrome mainly occurring in childhood which is now recognized as the most common food intolerance disease in the world. cd is associated with a wide spectrum of extra intestinal manifestations. neurological involvements of cd were first attributed to malabsorption due to changes in the mucosal architecture of the small intestine. neurological manifes...

(1) Background: Celiac disease (CD) patients can be affected by mouth and tooth disorders, which are influenced by their gluten-free diet. The aim of our research was to evaluate the pathological conditions of the stomatognathic system observed in celiac patients on a gluten-free diet. (2) Methods: we consecutively recruited celiac patients on a gluten-free diet at our celiac center, as well as...

Celiac disease (CD) is an autoimmune disorder that occurs in genetically susceptible individuals of all ages and is triggered by immune response to gluten and related proteins. The disease is characterized by the presence of HLA-DQ2 and/or -DQ8 haplotypes, diverse clinical manifestations, gluten-sensitive enteropathy, and production of several autoantibodies of which endomysial, tissue transglu...

Celiac disease (CD) is a gluten-sensitive enteropathy that develops in genetically susceptible individuals with permanent intolerance to wheat gliadin. CD is characterized by the presence of typical, though not specific, histopathological changes in the small intestinal mucosa. Reported CD prevalence among different countries varies between 1:70 and 1:200. Non-diarrheaassociated forms (silent, ...

Background Celiac disease (CD) is an autoimmune mediated gluten sensitive enteropathy and characterized by a wide range of clinical manifestations. The study aimed to compare Doppler tissue echocardiography findings between children with celiac disease and healthy children. Materials and Methods This case-control study was performed on 186 celiac and healthy children aged 6- 19 years.  Celiac d...