The present investigation was undertaken to explore the Antimutagenicity activity of Terminalia chebula on micronucleus formation and chromosomal aberration assay in bone marrow cells of Swiss albino mice. The protective effect of Terminalia chebula extract is reported against cyclophosphamide (CP)-induced micronuclei formation and chromosomal aberration in mouse bone marrow cells. The doses na...

PURPOSE The purpose of this study was to quantify accommodation-induced changes in the spherical aberration of cynomolgus monkey lenses. METHODS Twenty-four lenses from 20 cynomolgus monkeys (Macaca fascicularis; 4.4-16.0 years of age; postmortem time 13.5 ± 13.0 hours) were mounted in a lens stretcher. Lens spherical aberration was measured in the unstretched (accommodated) and stretched (re...

OBJECTIVES To assess the clinical utility of conventional karyotyping as a diagnostic tool in soft tissue tumours amidst the increasing use of molecular cytogenetics. DESIGN Case series. SETTING Singapore General Hospital, an Asian institution. PARTICIPANTS A total of 35 participants (18 male and 17 female) aged 15 to 81 years were included in this study. Conventional karyotyping of 35 co...

Cytogenetic analysis of hepatocellular carcinoma (HCC) cell lines and primary HCC tissues has demonstrated chromosome 1p to be the region most commonly affected. To refine the altered locus, genetic abnormalities of this region were surveyed systemically by microsatellite polymorphism analysis. Twelve sets of primers evenly distributed on chromosome 1p which can amplify di- or tetranucleotide r...

The main resolution limits in high-performance (S)TEM are due to the imperfections or ‘aberrations’ of the electron lenses. Correction of these aberrations requires the ability to quickly and accurately measure lens aberrations to align or ‘tune’ an aberration-corrector. The conventional method to measure aberrations in the TEM is to record a series of bright field (BF) images in a Zemlin table...

PURPOSE To determine the feasibility of creating customized multifocal and aspheric patterns onto a light-adjustable lens (LAL) using a digital light delivery (DLD) system. METHODS Silicone LALs were placed in a wet cell and irradiated in vitro using the DLD. Spatial intensity patterns were designed and generated to (1) create a multifocal optic with customized power and diameter and (2) simu...

We examine wave-front distortion caused by high-power lasers on transmissive optics using a Shack-Hartmann wave-front sensor. The coupling coefficient for a thermally aberrated Gaussian beam to the TEM(00) mode of a cavity was determined as a function of magnitude of the thermally induced aberration. One wave of thermally induced phase aberration between the Gaussian intensity peak and the 1/e(...

Electron holography has been shown to allow a posteriori aberration correction. Therefore, an aberration corrector in the transmission electron microscope does not seem to be needed with electron holography to achieve atomic lateral resolution. However, to reach a signal resolution sufficient for detecting single light atoms and very small interatomic fields, the aberration corrector has turned...

A wavefront sensorless adaptive optics technique was combined with a custom-made multiphoton microscope to correct for specimen-induced aberrations. A liquid-crystal-on-silicon (LCoS) modulator was used to systematically generate Zernike modes during image recording. The performance of the instrument was evaluated in samples providing different nonlinear signals and the benefit of correcting hi...

Over the past decade, a number of information forensic techniques have been developed to identify digital image manipulation and falsifications. However, recent research has shown that an intelligent forger can use antiforensic countermeasures to disguise their forgeries. In this paper, an anti-forensic technique is proposed to falsify the lateral chromatic aberration present in a digital image...