Significance T cells recognize their targets via T-cell receptors (TCRs), which in the case of CD8 + bind to MHC-I:antigen complexes on surface target cells. Many cancer evade immune recognition and killing by down-regulating MHC-I AgPPM. Here, we show how histone acetyl transferases p300/CBP together with NF-κB epigenetically regulate expression molecules, immunoproteasome subunits, peptide tr...

Influenza A viruses (IAVs) initiate infection via binding of the viral hemagglutinin (HA) to sialylated glycans on host cells. HA’s receptor specificity towards individual is well studied and clearly critical for virus infection, but contribution highly heterogeneous complex glycocalyx virus–cell adhesion remains elusive. Here, we use two complementary methods, glycan arrays single-virus force ...

the anti-cancer activity of metal ions in the lanthanide group is being considered recently. it has been reported that cerium salts might stimulate the metabolism and therefore, produce anti-cancer effects. however, little is known about the effects of protein-cerium complex in controlling cancer cell growth. the aim of the present study was to elucidate the possible pathways for the cytotoxic ...

psa is a 33-kda serine protease that is produced predominantly by prostate epithelium. however, it has been shown that about 30-40% of female breast tumors produce psa and its production is associated with the presence of estrogen and progesterone receptors. we have now developed a new tissue culture system to study psa production in breast cancer and its association with prognostic factors suc...

Here we present the use of surface nanopatterning covalently immobilized BMP-2 and integrin selective ligands to determine specificity their interactions in regulating cell adhesion focal assembly. Gold nanoparticle arrays carrying single dimers are prepared by block-copolymer micellar nanolithography azide-functionalized (cyclic-RGD peptides or ?5?1 peptidomimetics) on surrounding polyethylene...

Cancer is one of the leading causes death in world. Researchers keep attempting to develop therapy modalities decrease mortality and morbidity cancer patients by trying comprehend effect sympathetic nerves (through catecholamine adrenergic receptors) development. Catecholamine activation β-adrenergic receptors (β1-AR, β2-AR, β3-AR) may influence cytokine immunity system, initiate tumorigenesis,...

some lesions in the oral cavity and mostly on gingiva have predominant predilection towards females, and mostly occur in the first four decades of life when changes in sex hormone levels in blood are obvious. the present study aimed to investigate the presence and distribution of estrogen and progesterone receptors in peripheral giant cell granuloma (pgcg), pyogenic granuloma (pg) and periphera...

there is interrelationship between the immune and nervous systems that is accomplished by the molecular mediators. dopamine is one of the most important neurotransmitters. five different dopamine receptor genes (drd1, drd2, drd3, drd4, and drd5) have been recognized and cloned. the expression of the dopamine receptors is well characterized in the brain but little work has been done to examine t...