The in vitro generation of a three-dimensional (3-D) myocardial tissue-like construct employing cells, biomaterials, and biomolecules is a promising strategy in cardiac tissue regeneration, drug testing, and tissue engineering applications. Despite significant progress in this field, current cardiac tissue models are not yet able to stably maintain functional characteristics of cardiomyocytes f...

The in vitro generation of a three-dimensional (3-D) myocardial tissue-like construct employing cells, biomaterials, and biomolecules is a promising strategy in cardiac tissue regeneration, drug testing, and tissue engineering applications. Despite significant progress in this field, current cardiac tissue models are not yet able to stably maintain functional characteristics of cardiomyocytes f...

The morphology of a live cell reflects the organization of the cytoskeleton and the healthy status of the cell. We established a label-free platform for monitoring the changing morphology of live cells in real time based on scanning electrochemical microscopy (SECM). The dynamic morphology of a live human bladder cancer cell (T24) was revealed by time-lapse SECM with dissolved oxygen in the med...

eukaryotic cell physiology. In addition to producing ATP, they also regulate various cellular processes such as substrate utilization, redox homeostasis, intracellular calcium regulation and biosynthesis of macromolecules, as well as critical non-metabolic processes, particularly apoptosis. Mitochondria are known to undergo dramatic changes in morphology as cells grow, divide, and die. Mutation...

Several studies have shown that altered gravity causes changes in vestibular induced reflexes and behaviour, and in vestibular morphology. How the level of gravity affects the morphology of vestibular epithelia, however, is largely unknown. Vestibular epithelia of hypergravity (HG) exposed animals and control animals were histochemically labeled for actin and tubulin (two characteristic protein...

Effects of histatin-derived peptides immobilization by tresyl chloride-activation technique for MC3T3-E1 cellular responses on titanium (Ti) were evaluated. cultured sandblasted and acid-etched Ti disks immobilized with peptides, including histatin-1, JH8194, mixed histatin-1 JH8194. Surface topography morphology examined using a scanning electron microscope. Elemental composition conformationa...