Comparative physiology studies cellular, organ and organismic phenomena. It benefits from the diversity found in the animal kingdom. This diversity results from the enormous number of animal species and also from the size variation found among them. While describing the basic physiological systems in various animal groups it provides important basic information. The study of physiological varia...

Lysophosphatidic acid (LPA) and lysophosphatidylinositol bind to the G protein-coupled receptors (GPCRs) LPA GPR55, respectively. LPA2, a type 2 receptor, GPR55 are highly expressed in colon cancer involved progression. However, crosstalk between two potential effects on cellular physiology not fully understood. Here, using BRET analysis, we found that LPA2 interact live cells. In presence of b...

ABSTRACT First Person is a series of interviews with the first authors selection papers published in Journal Cell Science, helping early-career researchers promote themselves alongside their papers. François Tyckaert author on ‘ Rac1, actin cytoskeleton and microtubules are key players clathrin-independent endophilin-A3-mediated endocytosis’, JCS. conducted research described this article while...

Extensive research has been conducted to elucidate and substantiate the crucial role of Renin-Angiotensin System (RAS) in pathogenesis hypertension, cardiovascular disorders, renal diseases. Furthermore, oxidative stress maintaining vascular balance well established. It observed that many cellular effects induced by Angiotensin II (Ang II) are facilitated reactive oxygen species (ROS) produced ...

Gaseous molecules, such as hydrogen sulfide (H2S) and nitric oxide (NO), are crucial players in cellular (patho)physiological processes biological systems. The functions of these gaseous which were first discovered identified gasotransmitters animals, have received unprecedented attention from plant scientists recent decades. Researchers arrived at the consensus that H2S is synthesized endogeno...

Inositol phospholipids have been implicated in almost all aspects of cellular physiology including spatiotemporal regulation of cellular signaling, acquisition of cellular polarity, specification of membrane identity, cytoskeletal dynamics, and regulation of cellular adhesion, motility, and cytokinesis. In this review, we examine the critical role phosphoinositides play in these processes to ex...

The neurovascular unit, composed of neurons, brain endothelial cells, pericytes, microglia, and astrocytes, regulates cerebral blood flow. physical chemical signals govern the physiology unit within network its cellular components. Astrocytes have an essential role in this since they a privileged anatomical relationship with rest cells. They are capable sensing released by their neighboring rel...

Clinical physiologists in Sweden are physicians (the majority with a PhD degree) with thorough training in system physiology and pathophysiology. They investigate patients in a functional approach and are engaged in basic and applied physiology teaching and research. In 1954, clinical physiology was founded as an independent academic and clinical discipline by the Swedish government to ensure "...

To study the impact of neural activity on cellular physiology, one would like to combine precise control of firing patterns with highly sensitive probes of cellular physiology. Light-gated ion channels, e.g., Channelrhodopsin-2, enable precise control of firing patterns; green fluorescent protein-based reporters, e.g., the GCaMP6f Ca(2+) reporter, enable highly sensitive probing of cellular phy...