Investigators from Universities of Glasgow and Bristol, UK, determined the value of head circumference (HC) as a screening measure, the incidence of head centile shifting, and the relationship between extremes of head size and later neurodevelopmental problems.

We present a male infant with a giant omphalocele, diaphragmatic hernia, hepatic cyst, bilateral radioulnarsynostosis, absent leftthumb, and triphalangeal right thumb. History Prenatal. Polyhydramnios. Giant omphalocele shown by ultrasonography. Division of Clinical Genetics, Department of Paediatrics A, Rambam Medical Centre, PO Box 9602, 31096 Haifa, Israel. R Gershoni-Baruch Department of Ne...

Small fetuses are defined as those with an ultrasound estimated weight below a threshold, most commonly the 10th centile. The first clinically relevant step is the distinction of 'true' fetal growth restriction (FGR), associated with signs of abnormal fetoplacental function and poorer perinatal outcome, from constitutional small-for-gestational age, with a near-normal perinatal outcome. Nowaday...

One hundred and sixty four infants less than 5th centile for gestation specific birth weight were born at gestations greater than or equal to 37 weeks in the Cambridge Maternity Hospital in 1982. Of these, 60 were less than 2-3rd centile--that is, greater than 2 standard deviations below mean birth weight. Serious disease was rare: only six (4%) had recognisable malformations. There was only on...

The levels of the maternal serum markers alpha-fetoprotein (AFP), human chorionic gonadotrophin (hCG), and unconjugated oestriol (uE3) in 35 pregnant women with early second-trimester oligohydramnios differed from those in a reference population of 1699 singleton pregnancies. Maternal serum AFP levels above the 95th centile of the population distribution were observed in 80 per cent (16/20) of ...

INTRODUCTION The aim of this study was to explore the association between the cerebro-umbilical ratio measured at 35-37 weeks and intrapartum fetal compromise. METHODS This retrospective cross sectional study was conducted at the Mater Mothers' Hospital in Brisbane, Australia. Maternal demographics and fetal Doppler indices at 35-37 weeks gestation for 1381 women were correlated with intrapar...

We have studied maternal serum free beta-hCG and PAPP-A, and fetal nuchal translucency (NT) in a series of 46 cases of fetal Turner's syndrome, 13 cases of other sex chromosomal anomalies and compared these with 947 control pregnancies in the first trimester. In cases of Turner's syndrome (45,X) the median fetal NT was significantly higher than in controls (4.76 MoM), the median PAPP-A was sign...

OBJECTIVE To determine whether oral protein energy supplements, used long term in children with cystic fibrosis who are moderately malnourished, improve nutritional and other outcomes. DESIGN Multicentre randomised controlled trial. SETTING Seven specialist paediatric cystic fibrosis centres and their associated shared care clinics and seven smaller paediatric cystic fibrosis clinics. PAR...

OBJECTIVE Key components in the assessment of a child in the emergency department (ED) are their heart and respiratory rates. In order to interpret these signs, practitioners must know what is normal for a particular age. The aim of this paper is to develop age-specific centiles for these parameters and to compare centiles with the previously published work of Fleming and Bonafide, and the Adva...

BACKGROUND To study the outcome of cases with nuchal translucency (NT) ≥ 95th centile in the first trimester of pregnancy. METHODS This cross sectional study was performed at Iranian Fetal Medicine Foundation (FMF) between January 2009 and December 2011. Totally, 186 cases with NT≥ 95th centile who attended for the first trimester screening were studied. All cases with increased NT including ...