Primary central nervous system lymphoma (PCNSL) is characterized by extranodal malignant lymphomas arising in the brain, spinal cord, CSF, and eyes in the absence of lymphoma outside the nervous system at the time of diagnosis (Deckert & Paulus, 2007). By definition, this excludes CNS involvement of systemic lymphomas and angiotropic lymphomas (Schlegel et al., 2000). The incidence of PCNSL in ...

This chapter provides an overview of the major stages of prenatal central nervous system (CNS) development. CNS development plays the central role in the primary argument of this book. That argument is that the prenatal CNS is particularly vulnerable to environmental perturbations because it is rapidly developing during that time period. Further, we argue that many of the learning and behaviora...

This chapter provides an overview of the major stages of prenatal central nervous system (CNS) development. CNS development plays the central role in the primary argument of this book. That argument is that the prenatal CNS is particularly vulnerable to environmental perturbations because it is rapidly developing during that time period. Further, we argue that many of the learning and behaviora...

Widespread cell migrations are the hallmark of vertebrate brain development. In the early embryo, morphogenetic movements of precursor cells establish the rhombomeres of the hindbrain, the external germinal layer of the cerebellum, and the regional boundaries of the forebrain. In midgestation, after primary neurogenesis in compact ventricular zones has commenced, individual postmitotic cells un...