BACKGROUND AND PURPOSE Patients with carotid occlusive disease and stage 2 cerebral hemodynamic failure, characterized by an increased oxygen extraction fraction (OEF) as measured by positron emission tomography (PET) and otherwise known as misery perfusion, have a high risk of cerebral ischemia and subsequent stroke. In clinical practice, the detection of patients with misery perfusion through...

OBJECTIVE Angiotensin II (Ang II) exerts deleterious effect on the cerebral circulation through production of reactive oxygen species (ROS). However, the enzymatic source of the ROS has not been defined. We tested the hypothesis that Ang II impairs endothelium-dependent responses in the cerebral microcirculation through ROS generated in cerebrovascular cells by the enzyme NADPH oxidase. METHO...

BACKGROUND There is some evidence to suggest that the standard of acute medical care provided to patients with cerebrovascular disease is a major determinant of the eventual outcome. Consequently, the Royal College of Physicians (RCP) of London issues periodic guidelines to assist healthcare providers in the management of patients presenting with stroke. OBJECTIVE An audit of the acute manage...

background: stroke is the main cause of physical disability and the second leading cause of death worldwide. two-thirds of all strokes occur in the developing countries. despite being preventable, stroke is increasingly becoming a major health issue in these countries. the aim of this study was to evaluate the epidemiology of stroke in shiraz, iran, one of the main referral centers in the south...

Moyamoya disease (MD) is a chronic, progressive cerebrovascular disease distinguished by bilateral stenosis or occlusion of the arteries around the circle of Willis with resulting prominent arterial collateral circulation. We describe a pregnant woman in whom this diagnosis was confirmed by cerebral angiogram and treated with bilateral superficial temporal artery-middle cerebral artery (STA-MCA...

Posterior circulation vascular occlusive disease in children is a rare and uncommonly reported event. Among the numerous risk factors, the methylenetetrahydrofolate reductase (MTHFR) mutation is considered to be a common genetic cause of thrombosis in adults and children. Recently, a link between the MTHFR mutation and cerebrovascular disorders was reported in children. Diffusion tensor imaging...

We report a patient with three cerebrovascular events involving the posterior circulation, one of which occurred in conjunction with central retinal artery occlusion. The patient had constitutional findings but had a normal cardiac examination, negative echocardiogram, and negative blood cultures. Angiography on two separate occasions revealed left vertebral artery occlusion. Repeat echocardiog...

Patent foramen ovale is frequently associated with embolic cerebrovascular accidents. The diagnosis of patent foramen ovale (PFO) is easier since the advent of transesophageal echocardiography but is invasive and does not allow to detect extracardiac RLS. Contrast transcranial Doppler ultrasound enables the detection of the passage of a contrast material injected into a peripheral vein to the c...