isocitric dehydrogenase (ICD) activity of the cerebrospinal fluid was measured on 88 children with various disorders of the central nervous system and on 19 children with non-neurologic diseases , the latter serving as controls. The cerebrospinal fluid ICD activity ranged from 0.9 to 7 .7 units with a mean of 4.2•}2.1 units in the control series, and was elevated in 7 out of 33 patients with ce...

Human apolipoprotein E (apoE) has 3 isoforms: apoE2, apoE3, and apoE4. APOE4 is a major genetic risk factor for Alzheimer disease and is associated with dementia in Down syndrome and poor neurological outcome after traumatic brain injury, cerebral hemorrhage, and other neuropathological disorders. While apoE4 can induce neuropathology by participating in various cellular and molecular pathways,...

PRIMARY OBJECTIVE To investigate the status of the cerebrovasculature following repetitive mild traumatic brain injury (r-mTBI). RESEARCH DESIGN TBI is a risk factor for development of various neurodegenerative disorders. A common feature of neurodegenerative disease is cerebrovascular dysfunction which includes alterations in cerebral blood flow (CBF). TBI can result in transient reductions ...

The role of the blood-brain barrier (BBB) in epilepsy has evolved from an obstacle for drug brain delivery to an etiological factor contributing to seizures. Recent evidence has shown cerebrovascular angiogenesis and increased BBB permeability in the epileptic foci of patients and in experimental models of seizure. The molecular players involved in cerebrovascular remodeling in the epileptic br...

BACKGROUND A number of cerebrovascular disorders produce manifestations of neuro-ophthalmologic significance. In many cases, these disorders can be treated using endovascular techniques. METHODS The material in this article was obtained from a combination of personal experience and review of the literature using PubMed. RESULTS A variety of new equipment, materials, and techniques are avail...

background: resilience is a personal trait that can influence the stroke subjects’ attitudes toward future opportunities and facilitate the transitional process and adaptation in them. assessment of this trait in stroke subjects with a standardized tool would promote the rehabilitation protocols and occupational therapy interventions. therefore, the objective of this study was to standardize th...

Sleep-related breathing disorders, ranging from habitual snoring to the increased upper airway resistance syndrome to sleep apnea, are now recognized as major health problems. The majority of patients have excessive daytime sleepiness and tiredness. Neuropsychological dysfunction results in poor work performance, memory impairment, and even depression. Until recently, the coexistence of cardiov...

Hypertensive disorders of pregnancy are a major cause of poor outcome, including placental abruption, organ failure, cerebrovascular accident and disseminated intravascular coagulation. These disorders are associated with increased fetal risk of intrauterine growth restriction, intrauterine death and prematurity. Electrocardiography (ECG) recently emerged as a useful tool to evaluate cardiovasc...

Vascular brain diseases are one of the leading causes death and disability in developed countries. Along with acute disorders cerebral circulation, chronic cerebrovascular great medical social importance, main clinical manifestations is vascular cognitive impairments. The article discusses pathogenetic variants impairments, presents their modern classification approaches to diagnosis. importanc...

Neural interfaces are used to mitigate the burden of traumatic injuries, neurodegenerative diseases, and mental disorders. However, transient or permanent placement an interface in close contact with neural tissue requires invasive surgery, potentially entailing both short- long-term complications. To tackle this problem, a neurovascular for recording stimulation is developed. This endovascular...