INTRODUCTION Behçet's disease (BD) is a rare chronic inflammatory disorder of unknown aetiology. However, it has been postulated that a dysregulation of the prooxidant/antioxidant balance may be important to its pathogenesis. Ceruloplasmin (CP) is an acute phase protein expressed at the surface of peripheral blood lymphocytes (PBL) with antioxidant properties and with a relevant role in iron (F...

Wilson's disease is a rare but treatable condition with variable clinical presentations. Its diagnosis depends on a combination of clinical and laboratory findings. We evaluated the clinical and laboratory findings in children with Wilson's disease (WD). Twenty -seven children (4-14 years, 59.2 % male, 40.7% female) with confirmed WD were evaluated between 1994 and 2003 at Imam Khomeini Hos...

The aetio-pathogenesis of preeclampsia, a complication of pregnancy, is poorly understood. Oxidative stress has been shown to be the causative factor for hypertension as well as for target tissue damage in hypertension. Studies that explain the role of oxidative stress in preeclampsia have been few in number. The present study was aimed at (1) determining the extent of oxidative stress in preec...


 No evidence was identified regarding the diagnostic test accuracy or clinical utility of copper and ceruloplasmin tests compared to other criteria detect Wilson disease Menkes in children with global development delay intellectual disability that met for this review.
 evidence-based guidelines were found on use developmental

Injection into rabbits of radioactive ceruloplasmin from which sialic acid had been removed enzymatically resulted in a rapid disappearance of the asialoceruloplasmin from the seruni and its appearance in parenchymal cells, but not in Kupffer cells, of the liver. The rapidity of this transfer was dependent upon the presence of intact galactose residues as the terminal, nonreducing sugar of the ...

BACKGROUND Different methods for ceruloplasmin tend to give different results in external quality assessment schemes. During the production of the certified reference material ERM-DA470k/IFCC discrepant measurement results were also found for ceruloplasmin measured with different methods, and consequently the protein could not be certified in the material. METHODS We performed a commutability...

An automated micromethod is described for measurement of serum ceruloplasmin by assay of its p-phenylenediamine oxidase activity using the Abbott bichoromatic analyzer. Ten mul of serum are mixed with 250 mul of p-phenylenediamine (PPD) substrate (9.2 mmole per liter) in acetate buffer (0.1 mole per liter, pH 5.45). Spectrophotometric measurements of the rate of formation of the purple oxidatio...