Secreted protein acidic and rich in cysteine (SPARC) is associated with the progression of numerous types of cancer. However, the role of SPARC in the progression of cervical cancer has not yet been adequately elucidated. In the current study, reverse transcription-quantitative polymerase chain reaction (RT-qPCR) and immunohistochemistry were employed to evaluate the mRNA and protein expression...

Necrotizing fasciitis is a rare but rapidly progressive condition, with high morbidity and mortality rate. This spreading soft tissue infection rarely occurs in the head neck region, when it does most caused by odontogenic origin. A variety of host factors such as immune status, hygienic practices socio-economic status are role players disease process. case report documents 38-year old male who...

Ovarian tumors can be classified by their origin - epithelial tumors, germ cell and stromal tumors. Malignant struma ovarii (MSO) are 0.01% of all ovarian In order to as a ovarii, more than 50% the teratoma consists thyroid tissue. The tissue in exhibits same histological physiological properties that cervical Poorly differentiated carcinoma (PDTC) is an extremely rare occurrence when arising f...

BACKGROUND Cervical cancer is the leading cause of cancer related deaths among women in India. Limited reports are available for Notch-1 and Notch-3 protein in cervical carcinoma, which play crucial role in cell proliferation, differentiation, and apoptosis. METHODS This study was designed to evaluate the role of Notch-1 and Notch-3 with context to HPV infection in cervical carcinoma. A total...

Though the long noncoding RNA colon cancer associated transcript-1 (CCAT-1) has been shown to be involved in tumors of other tissues, its involvement in cervical cancer is still unknown. Therefore, the aim of this study was to investigate the molecular mechanism of CCAT-1 in cervical cancer. We quantified the expression of CCAT-1 long noncoding RNA in samples of cervical cancer tissue by real-t...

Ataxin-1 (ATXN1) is a coregulator protein within which expansion of the polyglutamine tract causes spinocerebellar ataxia type 1, an autosomal dominant neurodegenerative disorder. Previously, we reported that ATXN1 regulates the epithelial-mesenchymal transition of cervical cancer cells. In the present study, we demonstrate that ATXN1 is involved in cervical cancer tumorigenesis by promoting th...

BACKGROUND Free tissue reconstruction after ablation of head and neck malignancy often requires extensive cervical manipulation, which may exacerbate preexisting cervical spondylosis and result in progression to cervical myelopathy. We present a rare case of postoperative quadriplegia caused by cervical spondylotic myelopathy after head and neck reconstruction. METHODS AND RESULTS A 63-year-o...

Kinematic magnetic resonance imaging can be implemented as a non-invasive adjunct examination for injuries in the cervical spine in the clinical assessment of ligamentous, disk, and soft tissue injuries, as a basis for determining medical versus surgical management, and also establishing the degree of functional clinical impairment. This article discusses the clinical indications and applicatio...

Kinematic magnetic resonance imaging can be implemented as a noninvasive adjunct examination for injuries in the cervical spine in the clinical assessment of ligamentous, disk, and soft-tissue injuries, as a basis for determining medical vs. surgical management, and in establishing the degree of functional clinical impairment. This article discusses the clinical indications and application of k...

Cervical cancer is an infectious cancer and the most common gynecologic cancer worldwide. E6/E7, the early genes of the high-risk mucosal human papillomavirus type, play key roles in the carcinogenic process of cervical cancer. However, little was known about its roles in modulating tumor microenvironment, particular extracellular matrix (ECM). In this study, we found that E6/E7 could regulate ...