BACKGROUND The combination between cetirizine (CET), phenylpropanolamine (PPA) and nimesulide (NMS) under trade name Nemeriv Cp tablet is prescribed for nasal congestion, cold, sneezing, and allergy. Among all published methods for the three drugs; there is no reported method concerning estimation of CTZ, PPA and NMS simultaneously and this motivates us to develop new and simple methods for the...

A 12-year-old girl presented with an erythematous, papular, occasionally pruritic eruption covering both her legs. Her main complaint was aesthetic. The rash consisted of grouped red papules 10 ^ 15 mm in size. The patient was afebrile and reported no arthralgia or any other systemic symptoms. She denied any recent arthropod bite, viral or fungal infection, or ingestion of any kind of drug. The...

Objective: In the present research work, aim was to prepare pH trigged in-situ ocular gel of Cetirizine Hydrochloride (CTZ) improve its local bioavailability at eye surface. Methods: CTZ prepared by pH-trigged method. In-situ a pH-sensitive gelling agent (Carbomer) with one-viscosity builder polymer (HPMC E4M). All formulation evaluated for appearance, pH, viscosity different capacity, % drug c...

A nanocomposite electrode of graphene (Gr) and zinc oxide (ZnO) nanoparticles was fabricated to study the electrochemical oxidation behavior an anti-inflammatory drug, i.e., cetirizine (CET). The voltametric response CET for bare CPE, Gr/CPE, ZnO/CPE, ZnO-Gr studied. modifier materials were characterized using scanning electron microscopy (SEM), energy-dispersive X-ray spectroscopy (EDS), powde...

Abstract Background Present work describes a fast, simple, and sensitive procedure for the simultaneous determination of cetirizine in presence quinolones using diclofenac sodium as an internal standard. The present was designed to analyze these compounds pharmaceutical clinical labs being economical use. Results mobile phase consisted simple composition methanol, acetonitrile, water ratio 50:2...

An Optimized LC-MS condition was proposed for the estimation in human plasma. Cetrizine had been chromatographed on a C18 column with a mobile phase Water and Methanol in the ratio of 60:40v/v. the mobile phase was pumped in the flow rate of 0.5ml/min. Erythromycin was used as an internal standard and eluents were monitored at 749 nm. The data presented in this report were validated for the est...

The antiallergic activity of betotastine besilate was evaluated in comparison to that of other compounds in various rat models of allergy. Betotastine besilate inhibited histamine release from rat peritoneal mast cells and inhibited LTB4 and 5-HETE production in peritoneal cells at high concentrations (1 mM). Following oral administration at doses ranging from 0.1-30 mg/kg p.o., betotastine inh...