purpose: to present 3 rare cases of benign flecked retina syndrome. patients and finding: a 19-year-old female patient presented with fundus albipunctatus appearance in fundoscopy without night blindness and normal dark adaptation time on electeroretinography (erg). after 9 years of follow up, no change in visual acuity, erg, or other ophthalmologic examinations was seen. two members of her fam...

The health awareness recently shown by consumers has led to a demand for health beneficial products. In particular, researchers are currently focusing their studies on the search for foods for cancer prevention activity. In the present work, we study comparatively the effect of two different processing methods on the contents of phenolic compounds (i.e., ellagic acid, myricetin, quercetin and k...

We study the phase diagram of the continuum traffic flow model of a highway with an on-ramp. Using an open boundary condition, traffic states and metastabilities are investigated numerically for several representative values of the upstream boundary flux f(up) and for the whole range of the on-ramp flux f(rmp). An inhomogeneous but time-independent traffic state (standing localized cluster stat...

Kaptein RG and Van Gisbergen JAM. Effect of gravity cues on spatial updatingduring sinusoidal rotation. Program No. 168.6. Abstract viewer/Itinerary Planner.Washington, DC: Society for Neuroscience, 2005 Kaptein RG and Van Gisbergen JAM. Bistable perception of verticality duringroll tilt. Program No. 868.3. Abstract Viewer/Itinerary Planner. Washington, DC:Society for Neuroscien...

purpose : to evaluate the incidence of leber’s congenital amaurosis (lca) in low vision children referred to electrophysiology ward of farabi eye hospital , and review the clinical features of disease and electroretiongraphy (erg) test values to confirm the diagnosis and severity of the disease in iran . design: prospective observational case series methods : two-hundred and fifteen cases of lo...

A step toward the molecular classification of prostate cancer was the discovery of recurrent erythroblast transformation-specific rearrangements, most commonly fusing the androgen-regulated TMPRSS2 promoter to ERG. The TMPRSS2-ERG fusion is observed in around 90% of tumors that overexpress the oncogene ERG. The goal of the current study was to complete the characterization of these ERG-overexpr...

Mammalian Reovirus is a double-stranded RNA virus with a distinctive preference to replicate in and lyse transformed cells. On that account, Reovirus type 3 Dearing (T3D) is clinically evaluated as oncolytic agent. The therapeutic efficacy of this approach depends in part on the accessibility of the reovirus receptor Junction Adhesion Molecule-A (JAM-A) on the target cells. Here, we describe th...

Cell-cell adhesion plays a critical role in the formation of barrier-forming epithelia. The molecules which mediate cell-cell adhesion frequently act as signaling molecules by recruiting and/or assembling cytoplasmic protein complexes. Junctional Adhesion Molecule (JAM)-A interacts with the cell polarity protein PAR-3, a member of the PAR-3-aPKC-PAR-6 complex, which regulates the formation of c...

Tight junctions are the most apical components of endothelial and epithelial intercellular cleft. In the endothelium these structures play an important role in the control of paracellular permeability to circulating cells and solutes. The only known integral membrane protein localized at sites of membrane-membrane interaction of tight junctions is occludin, which is linked inside the cells to a...

Leukocyte recruitment from blood to inflammatory sites occurs in a multistep process that involves discrete molecular interactions between circulating and endothelial cells. Junctional adhesion molecule (JAM)-C is expressed at different levels on endothelial cells of lymphoid organs and peripheral tissues and has been proposed to regulate neutrophil migration by its interaction with the leukocy...