Ca2+ entry into different diameter cell bodies of dorsal root ganglion (DRG) neurons depolarized with action potential (AP) waveform commands was studied using the whole-cell patch-clamp technique and pharmacological probes. We have previously shown that Ca2+ current expression in DRG neuron cell bodies depends on cell diameter. In small diameter DRG neurons, L- and N-type Ca2+ currents usually...

Experiments were performed to determine the role of L-type calcium channels on the afferent arteriolar vasoconstrictor response to ATP and UTP. With the use of the blood-perfused juxtamedullary nephron technique, kidneys were perfused at 110 mmHg and the responses of arterioles to alpha,beta-methylene ATP, ATP, and UTP were determined before and during calcium channel blockade with diltiazem. a...

Recently we reported the observation of superfluidity in solid He confined inside porous Vycor glass with characteristic pore diameter of 7 nm [1], porous gold with pore diameter of 490 nm [2] and also in bulk solid He [3]. In the bulk experiment solid helium is confined in an annular channel inside the torsion bob (see inset III of Fig.1). The width, depth and outer diameter of the channel are...

We report on observations of the onset of dissipation in superfluid 3He flowing through a single cylindrical channel of diameter d = O. 71xm and length L = 6.0 #m. We propose a model in which thermally activated phase slips in the order parameter can account for the observed onset of dissipation.

A device containing a 3D microchannel network (fabricated using sacrificial melt-spun microfibers) sandwiched between lithographically patterned microfluidic channels offers improved delivery of soluble compounds to a large volume compared to a simple stack of two microfluidic channel layers. With this improved delivery ability comes an increased fluidic resistance due to the tortuous network o...

Passage of a 10-keV electron beam through bundle hollow polysulfone fiber with an inner channel diameter 160 ± 60 µm was studied. The dependence the that passed channels on tilt angle respect to incident axis measured. fraction electrons energy loss less than 10% after passing also estimated.

One of reasons that researchers in recent years have tried to produce ultrafine grained materials is producing lightweight components with high strength and reliability. There are disparate methods for production of ultra-fine grain materials,one of which is severe plastic deformation method. Severe plastic deformation method comprises different processes, one of which is Parallel tubular chann...

In this paper, we perform two-dimensional simulations of cross-flow forward osmosis (FO) membrane modules in the presence of draw and feed channel spacers. For this purpose, the equations corresponding to the conservation of mass, momentum, and convection-diffusion for the mass fraction of solute are solved using a commercial finite volume flow solver. We consider six configurations of channel ...

We designed pressure driven chromatography system using 100 nm scale nanofluidic channel (extended nanochannel) for million plate numbers. The chromatography was performed utilizing a channel in an equivalent diameter of 300 nm and 89 mm long (the world’s longest nanochannel) with 35 fL injection volume. The theoretical plate numbers 36,000 were well accorded with theoreticallyestimated 39,000....

The fabrication and functionalization of synthetic nanochannels has in the last years become of increasing interest for basic research as well as for applications. Nanochannels have an especially high surface-to-volume ratio which makes them ideal for handling very small amounts of liquid in nanofluidic devices or for designing highly sensitive sensing elements. In contrast to their biological ...