Control of CTFR Channel Gating by Phosphorylation and Nucleotide Hydrolysis. Physiol. Rev. 79, Suppl.: S77-S107, 1999. - The cystic fibrosis transmembrane conductance regulator (CFTR) Cl- channel is the protein product of the gene defective in cystic fibrosis, the most common lethal genetic disease among Caucasians. Unlike any other known ion channel, CFTR belongs to the ATP-binding cassette su...

Pseudohypoaldosteronism type 1 (PHA-1) is an inherited disease characterized by severe neonatal salt-wasting and caused by mutations in subunits of the amiloride-sensitive epithelial sodium channel (ENaC). A missense mutation (G37S) of the human ENaC beta subunit that causes loss of ENaC function and PHA-1 replaces a glycine that is conserved in the N-terminus of all members of the ENaC gene fa...

twik2 ion channels (k2p6.1, encoded by a gene named kcnk6) belong to the family of two-pore domain potassium channels. twik2 is also considered as a “silent” channel because of its inability to produce measurable currents in heterologous expression systems and its intracellular retention. it is expressed in different mammalian tissues including lymphoid organs and the vascular system. however, ...

in wireless channel the noise has a zero mean. this channel property can be used in the enhancement of the noise performance in the digital receivers by oversampling the received signal and calculating the decision variable based on the time average of more than one sample of the received signal. the averaging process will reduce the effect of the noise in the decision variable that will approa...

Internet + platform recycling is a new model of that provides more ways to recycle WEEE. Considering consumers’ preference for channels, we construct single-channel reverse supply chain (Model-S) and two dual-channel models (Model-DU Model-DD) consisting recycler an e-platform consider the unified pricing differentiated strategies in models. By solving optimal decisions members using game theor...

The current cold-formed steel (CFS) design standards have not yet provided adequate methods for built-up nested CFS channel compression members, which may fail by either local or distortional buckling, despite several research studies in recent times. These proposed improved DSM based that led to capacity predictions with varying accuracy. Besides, there were some contradicting observations reg...

Long QT syndrome (LQT) is an inherited disorder that causes sudden death from cardiac arrhythmias, specifically torsade de pointes and ventricular fibrillation. We previously mapped three LQT loci: LQT1 on chromosome 11p15.5, LQT2 on 7q35-36, and LQT3 on 3p21-24. Here we report genetic linkage between LQT3 and polymorphisms within SCN5A, the cardiac sodium channel gene. Single strand conformati...

Chloride channels are known to play critical physiological roles in many cell types. Here, we describe the expression of anion channels using RNA Seq in primary cultures of human bronchial epithelial cells (hBECs). Chloride intracellular channel (CLIC) family members were the most abundant chloride channel transcripts, and CLIC1 showed the highest level of expression. In addition, we characteri...

Mammals maintain homeostatic control of their body temperature. Therefore, these organisms are expected to have adaptations that confer the ability to detect and react to both self and ambient temperature. Temperature-activated ion channels have been discovered to be the primary molecular determinants of thermosensation. The most representative group of these determinants constitutes members of...

Intelligent Resource Director (IRD), a feature of the IBM eServer zSeries processors and the z/OS operating system, manages multiple heterogeneous workloads with various business priorities toward achieving their goals. It establishes a more synergistic relationship with the Workload Manager (WLM) component of z/OS and the zSeries hardware, and augments the adjustments that WLM makes to local s...