نتایج جستجو برای: chelerythrine

تعداد نتایج: 636  

Journal: :Surgery 2012
Ye Zheng Jeffrey S Scow Judith A Duenes Michael G Sarr

BACKGROUND GLUT2 is translocated to the apical membrane of enterocytes exposed to glucose concentrations >∼50 mM. Mechanisms of GLUT2-mediated glucose uptake in cell culture models of enterocytes have not been studied. AIM To explore mechanism(s) of glucose uptake in 3 enterocyte-like cell lines. METHODS Glucose uptake was measured in Caco-2, RIE-1, and IEC-6 cell lines using varying concen...

Journal: :American journal of physiology. Heart and circulatory physiology 1998
C Adam Kirton Rodger Loutzenhiser

Myogenic vasoconstriction of the renal afferent arteriole contributes to the autoregulation of renal blood flow, glomerular filtration rate, and glomerular capillary pressure (PGC). The reactivity of the afferent arteriole to pressure and the efficiency of PGC control are subject to physiological and pathophysiological alterations, but the determinants of the myogenic response of this vessel ar...

Journal: :Journal of the American Society of Nephrology : JASN 2001
H T Lee C W Emala

Renal ischemic reperfusion (IR) injury is a significant clinical problem in anesthesia and surgery. Recently, it was demonstrated that both renal ischemic preconditioning (IPC) and systemic adenosine pretreatment protect against renal IR injury. In cardiac IPC, pertussis toxin-sensitive G-proteins (i.e., G(i/o)), protein kinase C (PKC), and ATP-sensitive potassium (K+(ATP)) channels are implica...

Journal: :Hypertension 2000
K Yasunari M Kohno H Kano M Minami J Yoshikawa

We examined involvement of the polyol pathway in high glucose-induced human coronary artery smooth muscle cell (SMC) migration using Boyden's chamber method. Chronic glucose treatment for 72 hours potentiated, in a concentration-dependent manner (5.6 to 22.2 mol/L), platelet-derived growth factor (PDGF) BB-mediated SMC migration. This potentiation was accompanied by an increase in PDGF BB bindi...

Journal: :Physical chemistry chemical physics : PCCP 2015
Lucy Haque Ankur Bikash Pradhan Sutanwi Bhuiya Suman Das

A comparative study on the interaction of a benzophenanthridine alkaloid chelerythrine (CHL) with RNA triplex poly(U).poly(A)*poly(U) (hereafter U.A*U, .(dot) and *(asterisk) represent Watson-Crick and Hoogsteen base pairing respectively) and its parent duplex poly(A).poly(U) (A.U) was carried out by using a combination of various spectroscopic, viscometric and calorimetric techniques. The inte...

Journal: :British journal of anaesthesia 2006
R A Bouwman F N G van't Hof W de Ruijter B J van Beek-Harmsen R J P Musters J J de Lange C Boer

BACKGROUND Sevoflurane protects the myocardium against ischaemic injury through protein kinase C (PKC) activation, mitochondrial K+ATP-channel (mitoK+ATP) opening and production of reactive oxygen species (ROS). However, it is unclear whether the type of ischaemia determines the involvement of these signalling molecules. We therefore investigated whether hypoxia (HYP) or metabolic inhibition (M...

Journal: :The Journal of pharmacology and experimental therapeutics 2008
Yi Jing Janet A Dowdy Michael R Van Scott Jeffrey S Fedan

Exercise-induced airway obstruction is thought to involve evaporative water loss and hyperosmolarity of the airway surface liquid. Hyperosmolar challenge of the epithelium of isolated, perfused guinea pig trachea rapidly alters transepithelial potential difference (V(t)), and it elicits smooth muscle relaxation mediated by epithelium-derived relaxing factor (EpDRF). In many cell types, protein ...

Journal: :American journal of physiology. Heart and circulatory physiology 2001
S Wang J Cone Y Liu

Whether the mitochondrial ATP-dependent potassium (mK(ATP)) channel is the trigger or the mediator of cardioprotection is controversial. We investigated the critical time sequences of mK(ATP) channel opening for cardioprotection in isolated rabbit hearts. Pretreatment with diazoxide (100 microM), a selective mK(ATP) channel opener, for 5 min followed by 10 min washout before the 30-min ischemia...

Journal: :Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2004
Pavel Kosina Daniela Walterová Jitka Ulrichová Václav Lichnovský Marie Stiborová Helena Rýdlová Jaroslav Vicar Vladimír Krecman Michael J Brabec Vilím Simánek

Sanguinaria canadesis, Chelidonium majus and Macleya cordata have been used for centuries as alternative medicines. Currently the extracts from these medicinal plants are components of veterinary and human phytopreparations, and of oral-hygiene agents. Sanguinarine and chelerythrine (SA/CHE) are biologically active components of these extracts. They display distinct antibacterial and anti-infla...

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