Tablets are one of the most popular and preferred solid dosage forms because they can be accurately dosed, easily manufactured and packaged on a large scale, have good physical and chemical stability, and can contribute to good patient compliance given their ease of administration. The ability to match doses to patients depends on the availability of multiple dose sizes and adequate dose-respon...

The work by He et al. (1) expressed concern that human albumin derived from plasma fractionation is associated with “an increasing public health concern with plasma-derived HAS with its potential risk for transmission of infectious pathogens such as hepatitis and HIV” (1). The work by He et al. (1) offered two references to support this statement, one of which included the unequivocal statement...

1Departments of Clinical Pharmacology and Toxicology, and Global Health, University of Toronto, Toronto, ON, Canada M5G 1L7 2 In Vitro Drug Safety and Biotechnology, University of Toronto, MaRS Discovery District, 101 College Street, Suite 300, Lab 351, Toronto, ON, Canada M5G 1L7 3Division of Gastroenterology, Jewish General Hospital and McGill University, Montreal, QC, Canada H9H 3L1 4Divisio...

As better drugs from a variety of pharmaceutical industry players enter a market with millions of untreated patients, U.S. spending on hepatitis C treatments is expected to rise from $2.1 billion in 2012 to $6.5 billion in 2022.

Growing concern about the environmental impact of ionizable and polar organic chemicals such as pesticides, pharmaceuticals and personal care products has lead to the inclusion of some in legislative and regulatory frameworks. It is expected that future monitoring requirements for these chemicals in aquatic environments will increase, along with the need for low cost monitoring and risk assessm...

A new method is presented to predict which donors and acceptors form hydrogen bonds in a crystal structure, based on the statistical analysis of hydrogen bonds in the Cambridge Structural Database (CSD). The method is named the logit hydrogen-bonding propensity (LHP) model. The approach has a potential application in identifying both likely and unusual hydrogen bonding, which can help to ration...

bees from buds and exudates of certain plant sources neighboring its hive, is considered to possess broad spectrum of biological activities and has historical utilization in folk medicine. Thus, it is extensively being used in health food, pharmaceutical preparations etc. The chemical consistency of propolis is highly dependent on the flora of the region from where it is collected. As a part of...

Consistency and coherence of gene expression data across multiple sites depends on several factors such as platform (oligo, cDNA, etc.), environmental conditions at each laboratory, and data quality. The Hepatotoxicity Working Group of the International Life Sciences Institute Health and Environmental Sciences Institute consortium on the application of genomics to mechanism-based risk assessmen...

Heterocycle-containing cyclic peptides are promising scaffolds for the pharmaceutical industry but their chemical synthesis is very challenging. A new universal method has been devised to prepare these compounds by using a set of engineered marine-derived enzymes and substrates obtained from a family of ribosomally produced and post-translationally modified peptides called the cyanobactins. The...

The NMR spectra of azo dyes, 5-arylazobarbituric (5a-g), 5-arylazo-1,3-dimethylbarbituric(6a-g) and 5-arylazothiobarbituric acids (7a-g) were studied in DMSO-d6 in differentconcentrations. An intramolecular hydrogen bond was observed and indicating that thehydrazone forms is mostly predominant. The peak of the hydrazone proton was severelybroadened and its chemical shift appeared at down field ...