Tendon disorders are frequent both in human and veterinary medicine with high re-injury rates and unsatisfactory therapeutic treatments. Application of naked, chemically-modified mRNA (cmRNA), encoding for therapeutic proteins, is an innovative approach to address tendon healing. In the current study, we demonstrated that injection of naked cmRNA, diluted in a glucose-containing solution, into ...

Carbon active chemically bonded ethylenediamine as one sorbents successfully were applied for the enrichment of trace amount of some metal ions. The influences of the variables including pH, amount of solid phase, sample flow rate, type and condition of eluting solution and sample volume on the metal ions recoveries were investigated. The method has high sorption-preconcentration efficiency eve...

ABSTRACT Coumermycin A1 was early recognized as a potentially useful antibiotic because of its very good spectrum of activity against gram-positive organisms (particularly against staphylococci), in addition to appreciable activity against a variety of gram-negative bacteria. However, in spite of its excellent in vitro activity, the insoluble character of coumermycin A1 made parenteral administ...

Understanding the interaction of biological molecules with materials is essential in view of the novel potential applications arising when these two are combined. To this end, we investigate the interaction of DNA with diamondoids, a broad family of tiny hydrogen-terminated diamond clusters with high technological potential. We model this interaction through quantum-mechanical computer simulati...

RNA interference technology has become a powerful laboratory tool to study gene function. Small interfering RNAs (siRNAs) have provided unprecedented opportunities for the development of new therapeutics in human diseases. Unfortunately, siRNA duplexes are not optimal drug-like molecules. The problems for their effective application are fundamentally delivery, stability and off-target effects. ...

1 Max Planck Institute for Solid State Research, Heisenbergstraße 1, 70569 Stuttgart, Germany 2 Danubia Nanotech s.r.o., Ilkovičova 3, 84104 Bratislava, Slovakia 3 Electron Microscopy Group of Materials Science, University of Ulm, Albert Einstein Allee 11, 89069 Ulm, Germany 4 The MacDiarmid Institute for Advanced Materials and Nanotechnology, Victoria University of Wellington, New Zealand 5 Sc...

Chemical modification provides solutions to many of the challenges facing siRNA therapeutics. This review examines the various siRNA modifications available, including every aspect of the RNA structure and siRNA duplex architecture. The applications of chemically modified siRNA are then examined, with a focus on specificity (elimination of immune effects and hybridization-dependent off-target e...

Commercially available 1,2-PB was transformed into a well-defined reactive intermediate by quantitative bromination. The brominated polymer was used as a polyfunctional macroinitiator for the cationic ring-opening polymerization of 2-ethyl-2-oxazoline to yield a water-soluble brush polymer. Nucleophilic substitution of bromide by 1-methyl imidazole resulted in the formation of polyelectrolyte c...

In nucleic acid nanotechnology, designed RNA molecules are widely explored because of their usability originating from RNA's structural and functional diversity. Herein, a method to design and prepare RNA nanostructures by employing DNA origami strategy was developed. A single-stranded RNA scaffold and staple RNA strands were used for the formation of RNA nanostructures. After the annealing of ...

The electrical conductance response of single ZnO microwire functionalized with amine-groups was tested upon an acid pH variation of a solution environment after integration on a customized gold electrode array chip. ZnO microwires were easily synthesized by hydrothermal route and chemically functionalized with aminopropyl groups. Single wires were deposited from the solution and then oriented ...