Primary Lymphoma of Bone (PLB) is a very rare neoplasm presenting most commonly with bone pain and swelling or as an incidental finding on imaging. PLB diagnosis requires tissue biopsy and Non-Hodgkin’s lymphoma (NHL) is the commonest sub-type. Disease staging includes thoracic-abdominal-pelvic computed tomography scan (CT), bone marrow biopsy and cerebrospinal fluid cytology. Chemo-immunothera...

Background Preoperative chemoradiotherapy (CRT) has been widely adopted as the standard of care for locally advanced rectal cancer in most western countries. However there has been a general exclusion of the elderly patients from neoadjuvant trials often due to concerns over their tolerance of surgery and/or (chemo)radiotherapy. Our aim was to compare the compliance to preoperative CRT of recta...

We report a case of rhabdomyosarcoma of the middle ear and mastoid in a 3-year-old boy. The patient was treated according to Intergroup Rhabdomyosarcoma Study IV protocol (chemo- and radiotherapy), and he experienced a complete remission. However 7 months after the completion of treatment, he experienced a recurrence at the primary site that spread to the brain. Despite treatment, the patient d...

BACKGROUND The results of the recently published large European randomised study in rectal cancer (European Organisation for Research and Treatment of Cancer 22921 trial) do not support current guidelines recommending postoperative chemotherapy for patients who have previously undergone preoperative radiochemotherapy or radiotherapy [radio(chemo)therapy]. To evaluate this discrepancy further, a...

Pancreatic cancer is an aggressive malignant solid tumor well-known by early metastasis, local invasion, resistance to standard chemo- and radiotherapy and poor prognosis. Increasing evidence indicates that pancreatic cancer is initiated and propagated by cancer stem cells (CSCs). Here we review the current research results regarding CSCs in pancreatic cancer and discuss the different markers i...

In addition to cytoreductive surgery, most patients with malignant gliomas also undergo radio- and chemotherapy. An improved understanding of the molecular genetic mechanisms underlying the radio- and chemosensitivity of gliomas may help to identify glioma patients who will benefit from aggressive and, therefore, potentially toxic adjuvant treatment. It may also allow for the development of new...

BACKGROUND Cancer-related fatigue (CRF) affects a majority of patients (pts) with symptoms lasting up to several years after finishing therapy. These symptoms lead to decreased health related quality of life. Fatigue during treatment for colorectal cancer is common, but poorly understood and can affect compliance with post-surgical cancer therapy. We examined the fatigue levels during first-lin...

Head and Neck Cancer (HNC) is a broad term that includes carcinomas arising from head and neck region and the most common type is squamous cell carcinoma [1]. HNC patients experience treatment-related complications that may interfere with health related quality of life (HRQOL [2]. Cancers of head and neck include malignant tumors of the buccal cavity, larynx, pharynx, thyroid, salivary glands, ...

Cervical cancer is very common among females. Surgery, chemotherapy and radiotherapy are different treatment options for cervical cancer. In 2018, the FIGO staging system has implemented lymph node status in criteria but didn’t consider number of positive nodes. The current guidelines recommends primary chemoradiotherapy to treat advanced stages combined regimens remains controversial, so this ...