Conventional cooperative protein folding invokes discrete ensembles of native and denatured state structures in separate free-energy wells. Unimodal noncooperative ("downhill") folding, however, proposes an ensemble of states occupying a single free-energy well for proteins folding at >/=4 x 10(4) s(-1) at 298 K. It is difficult to falsify unimodal mechanisms for such fast folding proteins by s...

1 Institute for Computational Engineering and Sciences, The University of Texas at Austin, Austin, TX 78712, USA 2 Chevron ETC, San Ramon, CA 94583, USA 3 ConocoPhillips, Houston, TX 77252, USA 4 Institute for Computational Engineering and Sciences, Department of Aerospace Engineering and Engineering Mechanics, The University of Texas at Austin, Austin, TX 78712, USA 5 Department of Petroleum a...

O presente trabalho pretende investigar a possibilidade de o princípio da deferência, conforme doutrina Chevron, ser utilizado como um instrumento freio às hipóteses controle discricionariedade do mérito administrativo pelo Poder Judiciário, servindo, assim, por corolário, mitigador ativismo judicial, bem balizador equilíbrio entre os poderes. Para tanto, será analisada evolução histórica papel...