Sclrostin is a biomarker interrupted in bone resorption process by binding to LRP5 and/or LRP6 family, and prevent Wingless-type signaling (Wnt) which important both development the maintain of mass. Sixty (60) patients with thalassemia major were enrolled from period 2/5/2021 1/9/2021 summer assessment role sclrostin predisposing for osteoporosis β-thalassemia (β-TM). Patients ages (2-40 year)...

Background: Expansion of bone marrow cavity and decreased cortical and trabecular bone tissues and osteoporosis are resulted from beta-thalassemia. The aim of this study was to assess bone mineral density (BMD) in patients with β thalassemia major and intermedia, and to determine their biochemical and hormonal profiles that may affect BMD. Materials and Methods: In a cross sectional study from ...

Abstract Background Knowledge of factors associated with quality of life in patients with thalassemia is necessary for creating appropriate clinical programs, social support, and improving treatment outcomes. The purpose of this study was to determine quality of life in children with thalassemia major at Center for Special Diseases of valiasr hospital in Birjand. Materials and Methods This...

Background: Thalassemia/haemoglobinopathy is a hereditary disease with increased erythropoiesis and expansion of the bone marrow cavity. Consequently, there is a reduction in trabecular bone tissue resulting in osteopenia/osteoporosis. The present study was performed to determine bone mineral density (BMD) in children and adolescents with major thalassemia and its correlation with serum fer...

background: advances in treatment of thalassemia major have improved the life expectancy of the patients and therefore their quality of life as other chronic diseases. this study was conducted to assess health- related quality of life in these patients in guilan province. methods: in a cross-sectional study, thirty-one children, aged 8-12 years, with β-thalassemia major were interviewed in guil...

background : treatment procedures are the most common sources of pain in children. children with chronic diseases such as thalassemia experience many pains during painful procedures including at times of diagnosis, treatment and control of their disease. several methods have been reported to reduce pain. clinical professionals usually use distraction techniques to reduce pain. however, there is...